Department of Metabolic and Endocrine Diseases, UMC Utrecht, and Netherlands Metabolomics Centre, Utrecht, 3508 AB, The Netherlands.
Biochem J. 2010 Oct 1;431(1):1-11. doi: 10.1042/BJ20100644.
P4 ATPases (subfamily IV P-type ATPases) form a specialized subfamily of P-type ATPases and have been implicated in phospholipid translocation from the exoplasmic to the cytoplasmic leaflet of biological membranes. Pivotal roles of P4 ATPases have been demonstrated in eukaryotes, ranging from yeast, fungi and plants to mice and humans. P4 ATPases might exert their cellular functions by combining enzymatic phospholipid translocation activity with an enzyme-independent action. The latter could be involved in the timely recruitment of proteins involved in cellular signalling, vesicle coat assembly and cytoskeleton regulation. In the present review, we outline the current knowledge of the biochemical and cellular functions of P4 ATPases in the eukaryotic membrane.
P4 ATPases（IV 型 P 型 ATP 酶亚家族）是 P 型 ATP 酶的一个特化亚家族，与生物膜中磷脂从外质小叶向细胞质小叶的移位有关。在真核生物中，从酵母、真菌和植物到老鼠和人类，P4 ATPase 的关键作用已经得到证实。P4 ATPase 可能通过将酶促磷脂移位活性与酶非依赖性作用相结合来发挥其细胞功能。后者可能涉及到及时招募参与细胞信号转导、囊泡外壳组装和细胞骨架调节的蛋白质。在本综述中，我们概述了真核细胞膜中 P4 ATPase 的生化和细胞功能的最新知识。
