Massachusetts Institute of Technology, Cambridge, MA 02139, USA.
Metabolism. 2010 Oct;59 Suppl 1:S37-40. doi: 10.1016/j.metabol.2010.07.008.
Although the pain of fibromyalgia usually is not preceded by an injury to the involved tissue, whereas that of the complex regional pain syndrome usually starts at a site of prior trauma or surgery, both disorders may share a common mechanism-pathologic sensitization of brain mechanisms that integrate nociceptive signals-and both apparently respond to treatment with ketamine, an anesthetic-analgesic agent whose actions include blockade of N-methyl-D-aspartate receptors. Ketamine's widespread illegal use as a recreational agent probably precludes developing it as a general treatment of centrally mediated pain disorders; however, its efficacy suggests that related, to-be-discovered agents could be useful.
虽然纤维肌痛的疼痛通常不是受累组织受伤引起的，而复杂区域疼痛综合征的疼痛通常起始于先前创伤或手术部位，但这两种疾病可能具有共同的机制——大脑整合伤害性信号的机制病理性敏化，而且两者显然都对氯胺酮（一种麻醉镇痛剂，其作用包括阻断 N-甲基-D-天冬氨酸受体）治疗有反应。氯胺酮作为娱乐性药物被广泛非法使用，可能会妨碍其开发为中枢介导疼痛障碍的一般治疗方法；然而，其疗效表明，相关的、有待发现的药物可能会有用。
