Andriuoli G, Bossi M, Caramazza I, Zoppetti G
Department of Pharmacology, Italfarmaco Research Center, Milan, Italy.
Haemostasis. 1990;20 Suppl 1:154-8. doi: 10.1159/000216174.
In a study investigating the bioavailability of heparin administered by different routes, we also compared its bioavailability in the dog after oral administration of two enteric-coated formulations, one containing a heparin preparation (ITF-300) and the other sodium heparin. After administration of the formulation containing sodium heparin, there was no heparin in plasma, but when the formulation containing ITF-300 was given, plasma heparin levels were detectable.
在一项研究不同给药途径的肝素生物利用度的实验中，我们还比较了两种肠溶制剂经口服给药后在犬体内的生物利用度，一种制剂含有肝素制剂（ITF-300），另一种含有肝素钠。给予含有肝素钠的制剂后，血浆中未检测到肝素，但给予含有ITF-300的制剂时，血浆肝素水平可被检测到。
