从麦冬（沿阶草）须根中分离得到的两种新呋甾烷醇糖苷

Two new furostanol glycosides from the fibrous root of Ophiopogon japonicus (Thunb.) Ker-Gawl.

作者信息

Duan Chang-Ling, Ma Xiao-Feng, Jiang Yong, Liu Jian-Xun, Tu Peng-Fei

机构信息

Xiyuan Hospital, China Academy of Chinese Medical Sciences, School of Pharmaceutical Sciences, Peking University, Beijing, China.

出版信息

J Asian Nat Prod Res. 2010 Sep;12(9):745-51. doi: 10.1080/10286020.2010.495332.

DOI:10.1080/10286020.2010.495332

PMID:20839120

Abstract

Two new furostanol glycosides, ophiopogonins H (1) and I (2), were isolated from the fibrous root of Ophiopogon japonicus. The structures of 1 and 2 were established as (25R)-26-[(O-β-D-glucopyranosyl-(1→2)-β-D-glucopyranosyl)]-22α-hydroxyfurost-5-ene-3-O-[α-L-rhamnopyranosyl-(1→2)]-β-D-glucopyranoside and (25R)-26-[(O-β-D-glucopyranosyl-(1→2)-β-D-glucopyranosyl)]-20α-hydroxyfurost-5,22-diene-3-O-[α-L-rhamnopyranosyl-(1→2)]-β-D-glucopyranoside on the basis of spectroscopic means including HR-ESI-MS, 1D and 2D NMR experiments.

摘要

从麦冬的须根中分离出两种新的呋甾烷醇糖苷，即麦冬皂苷H（1）和I（2）。基于高分辨电喷雾电离质谱（HR-ESI-MS）、一维和二维核磁共振实验等光谱手段，确定1和2的结构分别为(25R)-26-[(O-β-D-吡喃葡萄糖基-(1→2)-β-D-吡喃葡萄糖基)]-22α-羟基呋甾-5-烯-3-O-[α-L-鼠李糖基-(1→2)]-β-D-吡喃葡萄糖苷和(25R)-26-[(O-β-D-吡喃葡萄糖基-(1→2)-β-D-吡喃葡萄糖基)]-20α-羟基呋甾-5,22-二烯-3-O-[α-L-鼠李糖基-(1→2)]-β-D-吡喃葡萄糖苷。