两种来自麦冬的新型呋甾烷醇皂苷。

Two novel furostanol saponins from Ophiopogon japonicus.

作者信息

Zhang Tao, Zou Peng, Kang Li-Ping, Yu He-Shui, Liu Yi-Xun, Song Xin-Bo, Ma Bai-Ping

机构信息

Beijing Institute of Radiation Medicine, China.

出版信息

J Asian Nat Prod Res. 2009 Sep;11(9):824-31. doi: 10.1080/10286020903156265.

DOI:10.1080/10286020903156265

PMID:20183331

Abstract

Two novel furostanol saponins were isolated from the fresh tubers of Ophiopogon japonicus. Comprehensive spectroscopic analysis allowed the chemical structures of the compounds to be assigned as (25R)-26-[(O-beta-d-glucopyranosyl-(1 --> 2)-beta-d-glucopyranosyl)]-22alpha-hydroxyfurost-5-ene-3-O-beta-d-xylopyranosyl-(1 --> 4)-O-[alpha-l-rhamnopyranosyl-(1 --> 2)]-beta-d-glucopyranoside (1, ophiopogonin F) and (25R)-26-[(O-beta-d-glucopyranosyl-(1 --> 6)-beta-d-glucopyranosyl)]-22alpha-hydroxyfurost-5-ene-3-O-beta-d-xylopyranosyl-(1 --> 4)-O-[alpha-l-rhamnopyranosyl-(1 --> 2)]-beta-d-glucopyranoside (2, ophiopogonin G). The rare furostanol saponins with two glucosyl residues at C-26 position were isolated from the natural source for the first time.

摘要

从麦冬新鲜块茎中分离出两种新型呋甾烷醇皂苷。综合光谱分析确定了化合物的化学结构，分别为(25R)-26-[(O-β-D-吡喃葡萄糖基-(1→2)-β-D-吡喃葡萄糖基)]-22α-羟基呋甾-5-烯-3-O-β-D-吡喃木糖基-(1→4)-O-[α-L-吡喃鼠李糖基-(1→2)]-β-D-吡喃葡萄糖苷（1，麦冬皂苷F）和(25R)-26-[(O-β-D-吡喃葡萄糖基-(1→6)-β-D-吡喃葡萄糖基)]-22α-羟基呋甾-5-烯-3-O-β-D-吡喃木糖基-(1→4)-O-[α-L-吡喃鼠李糖基-(1→2)]-β-D-吡喃葡萄糖苷（2，麦冬皂苷G）。首次从天然来源中分离出在C-26位带有两个葡萄糖基残基的罕见呋甾烷醇皂苷。