Tsuji H, Murai K, Kobayashi K, Nishimura J, Sumiyoshi K, Akagi K, Fujishima M
Second Department of Internal Medicine, Faculty of Medicine, Kyushu University, Fukuoka, Japan.
Hepatogastroenterology. 1990 Dec;37 Suppl 2:97-9.
A 51-year-old Japanese woman with Budd-Chiari syndrome, following dermatoplasty of the leg for burns, developed multiple myeloma and amyloidosis during the four-year observation period. In Budd-Chiari syndrome, polyclonal hypergammaglobulinemia is frequently seen as the result of intestinal antigenic stimulation through the portacaval shunt. Although monoclonal gammopathy is occasionally presented in chronic liver diseases, multiple myeloma has not been previously recognized as occurring in association with Budd-Chiari syndrome. This case demonstrates that, in Budd-Chiari syndrome, the development of multiple myeloma may be the result of chronic stimulation of the intestinal microbes.
一名51岁的日本女性，因腿部烧伤接受皮肤移植术后患有布加综合征，在四年的观察期内发展为多发性骨髓瘤和淀粉样变性。在布加综合征中，由于通过门腔分流的肠道抗原刺激，多克隆高球蛋白血症很常见。虽然单克隆丙种球蛋白病偶尔出现在慢性肝病中，但此前尚未认识到多发性骨髓瘤与布加综合征有关。该病例表明，在布加综合征中，多发性骨髓瘤的发生可能是肠道微生物长期刺激的结果。
