Dobrzyńska Małgorzata M, Radzikowska Joanna
Zakład Ochrony Radiologicznej i Radiobiologii, Narodowy Instytut Zdrowia Publicznego-Państwowy Zakład Higieny, Warszawa.
Rocz Panstw Zakl Hig. 2010;61(2):129-33.
The aim of the study was to estimate the effects of bisphenol A and combined exposure to X-rays and bisphenol A on the induction of micronuclei in the blood and bone marrow reticulocytes. Pzh:Sfis male mice were irradiated (0.05 Gy and 0.10 Gy) or/and treated with bisphenol A (5 mg/kg mc, 10 mg/kg mc, 15 mg/kg mc, 20 mg/kg mc, 40 mg/kg mc) or exposed to combination of both (0.05 Gy + 5 mg/kg mc BPA lub 0.10 Gy + 10 mg/kg mc BPA) for 2 weeks. Bisphenol A as well as ionizing radiation alone stimulated induction of micronuclei in peripheral blood and bone marrow reticulocytes. Combined exposure of X-rays and bisphenol A induced higher frequency of micronuclei compared to effect produced by BPA alone. Sometimes, especially after combined exposure to low doses of both agents, observed effects enhanced that obtained following exposure to X-rays alone. Ionising radiation is probably the agent which decided about damage and/or unequal distribution of chromosomes following combined exposure together with bisphenol A, which seems to be weak mutagen.
本研究的目的是评估双酚A以及X射线与双酚A联合暴露对血液和骨髓网织红细胞中微核诱导的影响。将Pzh:Sfis雄性小鼠进行辐照（0.05 Gy和0.10 Gy）或/和用双酚A处理（5 mg/kg体重、10 mg/kg体重、15 mg/kg体重、20 mg/kg体重、40 mg/kg体重），或同时接受两者联合暴露（0.05 Gy + 5 mg/kg体重双酚A或0.10 Gy + 10 mg/kg体重双酚A），持续2周。双酚A以及单独的电离辐射均刺激外周血和骨髓网织红细胞中微核的诱导。与单独双酚A产生的效应相比，X射线与双酚A的联合暴露诱导了更高频率的微核。有时，特别是在联合暴露于两种低剂量试剂后，观察到的效应增强了单独暴露于X射线后获得的效应。电离辐射可能是决定联合暴露后染色体损伤和/或不均等分布的因素，而双酚A似乎是一种弱诱变剂。
