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小檗碱可降低地塞米松诱导的体外卵巢膜细胞胰岛素抵抗。

Berberine reduces insulin resistance induced by dexamethasone in theca cells in vitro.

机构信息

Department of Obstetrics and Gynecology, First Affiliated Hospital, Harbin Medical University, Harbin, People's Republic of China.

出版信息

Fertil Steril. 2011 Jan;95(1):461-3. doi: 10.1016/j.fertnstert.2010.07.1090. Epub 2010 Sep 16.

DOI:10.1016/j.fertnstert.2010.07.1090
PMID:20840879
Abstract

Theca cells with dexamethasone-induced insulin resistance showed defective glucose uptake and excessive testosterone production, both of which were effectively antagonized by berberine. Therefore, insulin-resistant theca cells may contribute to the pathogenesis of hyperandrogenism in polycystic ovary syndrome.

摘要

地塞米松诱导胰岛素抵抗的卵泡膜细胞表现出葡萄糖摄取缺陷和睾酮过度产生，这两种现象均被小檗碱有效拮抗。因此，胰岛素抵抗的卵泡膜细胞可能有助于多囊卵巢综合征高雄激素血症的发病机制。

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