Jakobovits Akos, Jakobovits Antal
Toldy Ferenc Kórház Szülészeti és Nogyógyászati Osztály Cegléd Pf. 63 2700.
Orv Hetil. 2010 Sep 26;151(39):1573-9. doi: 10.1556/OH.2010.28806.
This article discusses the role of the central nervous system and testosterone hormone and its derivatives in the intrauterine development of male reproductive organs. The characteristics that define male personality first emerge in fetal stage of human development. Thereafter they continue to evolve during childhood. They become increasingly apparent after puberty and then remain prevalent throughout the individual's life time. The cited process affects both male phenotype and masculine behavior. Testosterone and its derivatives control the development of male reproductive organs. Their absence leads to predominance of female sexual characteristics even in the presence of a male chromosome pattern. The clinical entity of testicular feminization is a typical example for this phenomenon. The presented study pays special attention to those abnormalities of male reproductive organs that are identifiable by ultrasound during the fetal period. Most of these anomalies cannot be treated effectively before birth. Those conditions that are also incurable in extra uterine life, may serve as indication for pregnancy termination if they can be detected by ultrasound examination in early gestation.
本文讨论了中枢神经系统以及睾酮激素及其衍生物在男性生殖器官子宫内发育过程中的作用。定义男性性格的特征首先在人类发育的胎儿阶段出现。此后，它们在儿童时期持续演变。在青春期后变得愈发明显，然后在个体的一生中都普遍存在。上述过程影响男性表型和男性行为。睾酮及其衍生物控制男性生殖器官的发育。它们的缺失会导致即使存在男性染色体模式，女性性特征也占主导地位。睾丸女性化的临床实体就是这一现象的典型例子。本研究特别关注那些在胎儿期可通过超声识别的男性生殖器官异常。这些异常中的大多数在出生前无法得到有效治疗。那些在子宫外生活中也无法治愈的情况，如果在妊娠早期能通过超声检查检测到，可能作为终止妊娠的指征。
