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Resolution of the enantiomers of omeprazole and some of its analogues by liquid chromatography on a trisphenylcarbamoylcellulose-based stationary phase. The effect of the enantiomers of omeprazole on gastric glands.

作者信息

Erlandsson P, Isaksson R, Lorentzon P, Lindberg P

机构信息

Department of Technical Analytical Chemistry, University of Lund, Sweden.

出版信息

J Chromatogr. 1990 Nov 16;532(2):305-19. doi: 10.1016/s0378-4347(00)83781-0.

DOI:10.1016/s0378-4347(00)83781-0
PMID:2084128
Abstract

The enantiomers of omeprazole and some of its analogues have been separated on a chiral stationary phase comprising trisphenylcarbamoylcellulose coated on 3-aminopropyl silica. The nature of the supporting silica has a crucial effect on the separations obtained. The racemisation half-life of omeprazole was estimated to be 1.3.10(2) h at 37 degrees C. In vitro tests on isolated gastric glands from rabbits showed that both enantiomers of omeprazole had an inhibitory effect on acid formation.

摘要

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