Department of Respiratory Medicine and Allergology, Institute of Internal Medicine, The Sahlgrenska Academy, University of Gothenburg, Göteborg, Sweden.
Int J Tuberc Lung Dis. 2010 Oct;14(10):1272-9.
Health care students in Sweden.
To analyse the distribution of tuberculin skin test (TST) reactions and epidemiological factors related to TST reactivity.
TST reactivity was analysed in 1190 students. A linear regression model was created for the relative contribution of background factors of TST reactivity. A subgroup of 287 non-vaccinated subjects was comparatively skin-tested with Mycobacterium avium sensitin and tuberculin.
Among non-bacille Calmette-Guérin (BCG) vaccinated students, 91% had no TST reaction (0 mm induration) and reactions of ≥ 10 mm were found in 2.9%, whereas 34% of BCG-vaccinated students had no TST reaction and 42% had reactions of ≥ 10 mm. The expected contribution to TST reactivity was 6.0 mm for a history of BCG vaccination, 3.0 mm for a country of birth with medium/high incidence of TB and 1.6 mm per 10 years of age. The sensitin reactions exceeded the TST reactions by ≥ 3 mm in 52% of the comparatively tested subjects with TST reactions of ≥ 1 mm.
BCG vaccination, cross-reactivity with non-tuberculous mycobacteria, geographic origin and age had a decisive influence on TST reactivity. Most non-vaccinated health care students were non-reactive, which highlights the need to organise preventive measures in settings where TB exposure is expected.
瑞典的医学生。
分析结核菌素皮肤试验（TST）反应的分布和与 TST 反应性相关的流行病学因素。
对 1190 名学生的 TST 反应性进行了分析。建立了一个线性回归模型，用于分析 TST 反应性的背景因素的相对贡献。对 287 名未接种疫苗的受试者进行了分枝杆菌 avium 敏感应试验和结核菌素皮肤试验的比较。
在未接种卡介苗（BCG）的学生中，91%无 TST 反应（硬结 0 毫米），≥10 毫米的反应占 2.9%，而 BCG 接种学生中无 TST 反应的占 34%，≥10 毫米的反应占 42%。BCG 接种史对 TST 反应性的预期贡献为 6.0 毫米，出生地为结核病中/高发病率国家为 3.0 毫米，年龄每增加 10 岁增加 1.6 毫米。在 TST 反应≥1 毫米的比较测试受试者中，有 52%的受试者的敏感应超过 TST 反应≥3 毫米。
BCG 接种、与非结核分枝杆菌的交叉反应、地理起源和年龄对 TST 反应性有决定性影响。大多数未接种疫苗的卫生保健学生无反应，这突出表明需要在预计会接触结核的环境中组织预防措施。
