Department of Immunology, Imperial College London, London W2 1PG, UK.
Trans R Soc Trop Med Hyg. 2010 Nov;104(11):746-8. doi: 10.1016/j.trstmh.2010.08.004. Epub 2010 Sep 17.
Arginase-induced L-arginine deprivation is emerging as a key mechanism for the downregulation of immune responses. We hypothesised that arginase activity increases with disease severity in HIV-seropositive patients. Our results show that peripheral blood mononuclear cells (PBMCs) from 23 HIV-seropositive patients with low CD4(+) T cell counts (≤350 cells/μl) expressed significantly more arginase compared with 21 patients with high CD4(+) T cell counts. Furthermore, we found a significant association between the two principal prognostic markers used to monitor HIV disease (CD4(+) T cell count and plasma viral load) and PBMC arginase activity in antiretroviral therapy naïve patients but not in patients undergoing therapy.
精氨酸酶诱导的精氨酸缺乏正在成为下调免疫反应的一个关键机制。我们假设，在 HIV 阳性患者中，精氨酸酶活性随着疾病的严重程度而增加。我们的结果表明，与 21 名 CD4+T 细胞计数较高（≥350 个/μl）的 HIV 阳性患者相比，23 名 CD4+T 细胞计数较低（≤350 个/μl）的 HIV 阳性患者外周血单核细胞（PBMC）表达的精氨酸酶明显更多。此外，我们发现在抗逆转录病毒治疗初治患者中，两种主要的用于监测 HIV 疾病的预后标志物（CD4+T 细胞计数和血浆病毒载量）与 PBMC 精氨酸酶活性之间存在显著关联，但在接受治疗的患者中则没有。
