Roshani Ali, Khosropanah Iraj, Salehi Mohammad, Kamran Alireza Noshad
Guilan Urology Research Center, Rasht, Iran.
Urol J. 2010 Summer;7(3):183-7.
To compare the immediate effects of a systemic nitric oxide (NO) donor with placebo on the uroflowmetric parameters in patients with benign prostatic hyperplasia (BPH).
Eighty patients with the mean age of 61.5 years (range, 49 to 74 years) who suffered from BPH were enrolled in the study. We examined peak flow rate, average flow rate, and residual urine in all the patients. Then, patients were randomized to receive either 20 mg sublingual isosorbide dinitrate (ISDN) (n = 40) or placebo (n = 40) 20 minutes prior to the second uroflowmetry, which was performed one day after the first test.
The mean peak flow rate increased from 7.6 ± 0.41 mL/s to 10.2 ± 0.54 mL/s (P = .013) in the ISDN group, while it increased +0.40 mL/s in the placebo group (P > .05). Mean residual urine volume decreased significantly from 51 ± 3.1 mL to 29 ± 2.9 mL and from 56 ± 4.1 to 51 ± 2.6 in the ISDN (P = .02) and the placebo groups (P > .05), respectively. At baseline, the mean arterial pressure was 95 ± 2.1 mmHg and under the influence of the NO-donor, it decreased to 83 ± 1.9 mmHg, which was significant (P < .001). No significant changes of micturition parameters were found in the placebo group.
Organic nitrates influence micturition parameters in patients with BPH. This new approach could offer a potential pharmacological option to treat obstructive lower urinary tract symptoms.
比较系统性一氧化氮（NO）供体与安慰剂对良性前列腺增生（BPH）患者尿流率参数的即时影响。
80例平均年龄61.5岁（范围49至74岁）的BPH患者纳入本研究。我们检测了所有患者的最大尿流率、平均尿流率和残余尿量。然后，患者被随机分为两组，在第二次尿流率检测前20分钟，一组舌下含服20mg硝酸异山梨酯（ISDN）（n = 40），另一组服用安慰剂（n = 40）。第二次尿流率检测在第一次检测后一天进行。
ISDN组的平均最大尿流率从7.6±0.41mL/s增至10.2±0.54mL/s（P = 0.013），而安慰剂组仅增加了0.40mL/s（P>0.05）。ISDN组（P = 0.02）和安慰剂组（P>0.05）的平均残余尿量分别从51±3.1mL显著降至29±2.9mL和从56±4.1降至51±2.6mL。基线时，平均动脉压为95±2.1mmHg，在NO供体的影响下，降至83±1.9mmHg，差异有统计学意义（P<0.001）。安慰剂组排尿参数无显著变化。
有机硝酸盐可影响BPH患者的排尿参数。这种新方法可能为治疗下尿路梗阻症状提供一种潜在的药理学选择。
