Department of Chemical and Biochemical Engineering, The University of Iowa, Iowa City, Iowa 52242, USA.
J Pharm Sci. 2010 Nov;99(11):4477-87. doi: 10.1002/jps.22167.
A model was developed and compared to experimental results for prediction of the induction period during drug delivery from various compositions of biodegradable copolymer PLGA microparticles. The uniqueness of this model is that it considers transient pore evolvement and uses the kinetic parameters of polymer degradation, which are independent of experimental measurements of microparticle erosion, in its analysis. Delivery data from PLGA microparticles (50:50, 75:25, and 85:15) releasing ovalbumin (OVA, 46 kDa) and bovine serum albumin (BSA, 66 kDa) were determined and used as the model systems. Experimental measurements were carried out from 85 to 150 days depending on the PLGA characteristics. The predicted induction periods were approximately 45, 70, and 105 days for the release of both OVA and BSA from 50:50, 75:25, and 85:15 PLGA microparticles, respectively. Overall, these values were in very good agreement with experimentally estimated results.
针对不同组成的可生物降解共聚物 PLGA 微球中药物传递的诱导期预测，建立并比较了一个模型。该模型的独特之处在于它考虑了瞬态孔演变，并在分析中使用了聚合物降解的动力学参数，而这些参数与微球侵蚀的实验测量无关。从释放卵清蛋白（OVA，46 kDa）和牛血清白蛋白（BSA，66 kDa）的 PLGA 微球（50:50、75:25 和 85:15）中确定并使用了输送数据作为模型系统。根据 PLGA 的特性，实验测量时间从 85 天到 150 天不等。对于从 50:50、75:25 和 85:15 的 PLGA 微球中释放 OVA 和 BSA，预测的诱导期分别约为 45、70 和 105 天。总体而言，这些值与实验估计结果非常吻合。
