Department of Pharmaceutical Technology and Drug Delivery System Excellence Center, Faculty of Pharmaceutical Sciences, Prince of Songkla University, Hat Yai Songkla 90112, Thailand.
J Pharm Sci. 2010 Nov;99(11):4593-602. doi: 10.1002/jps.22176.
A cholesteryl carbonate ester was prepared and evaluated as a possible thermotropic liquid crystal excipient for dry powder inhalers. Cholesteryl palmityl carbonate (CPC) was synthesized, and the phase behavior was characterized by differential scanning calorimetry, transmission electron microscopy, polarized light microscope, small angle X-ray diffraction, and solid-state nuclear magnetic resonance spectroscopy. Amphotericin B (AmB) was incorporated into CPC at various mole% (7.7, 14.3, 25, 33.3, and 50) using a solvent evaporation method. The amount of AmB loaded into liquid crystal was limited. The mixture of AmB in liquid crystal did not produce a new complex; rather, the addition of AmB affected the orientational order and the motional aspects of liquid crystal molecules.
一种胆甾醇碳酸酯酯被制备并评估为干粉吸入剂的可能热致液晶赋形剂。胆甾醇棕榈酸酯碳酸酯（CPC）被合成，并且通过差示扫描量热法、透射电子显微镜、偏光显微镜、小角 X 射线衍射和固态核磁共振波谱法来表征其相行为。两性霉素 B（AmB）通过溶剂蒸发法以不同的摩尔%（7.7、14.3、25、33.3 和 50）掺入 CPC 中。进入液晶的 AmB 的量是有限的。在液晶中的 AmB 的混合物没有产生新的复合物；相反，添加 AmB 影响液晶分子的取向有序和运动方面。
