Yamamoto Tetsuo, Asakura Kohji, Shirasaki Hideaki, Himi Tetsuo
Yamamoto ENT Clinic, Sapporo.
Nihon Jibiinkoka Gakkai Kaiho. 2010 Aug;113(8):661-9. doi: 10.3950/jibiinkoka.113.661.
Persons allergic to birch pollen often report oral and pharyngeal hypersensitivity to fruit and vegetables, such as apples and peaches due to immunological cross-reactivity, or oral allergy syndrome (OAS) sometimes accompanied by systemic reaction. Such cross-reactive antigen reactions involve Bet v 1, the main birch-pollen allergen, and Bet v 2, birch-pollen profilin. We evaluated the food/antigen relationship.
Subjects interviewed numbered 60-40 women and 20 men aged 12 to 70 (mean age: 35 years)-suffering OAS episodes and having IgE birch-pollen antibodies. Using CAP scoring we examined IgE antibodies to recombinant Bet v 1 (rBet v 1), recombinant Bet v 2 (rBet v 2), and recombinant Pru p 3 (rPru p 3) a peach lipid transfer protein (LTP). A CAP score of 0.35 or more was considered positive. We evaluated the relationship between recombinant allergens and 9 fruit often involving OAS--apple, peach, cherry, kiwi, pear, melon, plum, strawberry, and watermelon-based on subjects' reports.
Of the 60, all (100%) were rBet v 1-positive, 9 (15%) rBet v 2-positive, and none (0%) rPru p 3-positive. Rose-family fruit-apples, peaches, cherries, pears, plums, and strawberries-often caused OAS regardless of positive or negative rBet v 2 CAP and were associated with rBet v 1. In contrast, more of those who were rBet v 2 CAP-positive had OAS to non-rose-family fruit-melon and watermelon-than those rBet v 2-negative. In rose-family and non-rose-family classification of the 9 fruit, cluster analysis and kappa statistics showed non-rose-family melon, watermelon, and kiwi to be associated with rBet v 2, as were grass and mugwort pollen allergies.
Bet v 1 is associated with OAS due to rose-family fruit and Bet v 2 with OAS due to non-rose-family fruit.
对桦树花粉过敏的人常因免疫交叉反应而报告对水果和蔬菜（如苹果和桃子）有口腔和咽部过敏反应，即有时伴有全身反应的口腔过敏综合征（OAS）。这种交叉反应性抗原反应涉及主要的桦树花粉过敏原Bet v 1和桦树花粉肌动蛋白结合蛋白Bet v 2。我们评估了食物/抗原关系。
采访对象为60名女性和20名男性，年龄在12至70岁之间（平均年龄：35岁），患有OAS发作且有IgE桦树花粉抗体。使用CAP评分法，我们检测了针对重组Bet v 1（rBet v 1）、重组Bet v 2（rBet v 2）和重组桃脂质转移蛋白（LTP）Pru p 3（rPru p 3）的IgE抗体。CAP评分为0.35或更高被视为阳性。我们根据受试者的报告评估了重组过敏原与9种常引发OAS的水果（苹果、桃子、樱桃、猕猴桃、梨、甜瓜、李子、草莓和西瓜）之间的关系。
60名受试者中，所有受试者（100%）rBet v 1呈阳性，9名（15%）rBet v 2呈阳性，无受试者（0%）rPru p 3呈阳性。蔷薇科水果（苹果、桃子、樱桃、梨、李子和草莓）无论rBet v 2 CAP阳性或阴性，都常引发OAS，且与rBet v 1相关。相比之下，rBet v 2 CAP呈阳性的受试者中，对非蔷薇科水果（甜瓜和西瓜）出现OAS的比例高于rBet v 2呈阴性的受试者。在这9种水果的蔷薇科和非蔷薇科分类中，聚类分析和kappa统计显示，非蔷薇科的甜瓜、西瓜和猕猴桃与rBet v 2相关，禾本科和艾蒿花粉过敏也与之相关。
Bet v 1与蔷薇科水果引发的OAS相关，Bet v 2与非蔷薇科水果引发的OAS相关。
