Qian Juying, Chen Zhangwei, Ge Junbo, Ma Jianying, Chang Shufu, Fan Bing, Liu Xuebo, Ge Lei
Department of Cardiology, Shanghai Institute of Cardiovascular Diseases, Zhongshan Hospital, Fudan University, Shanghai 200032, PR China.
J Heart Valve Dis. 2010 Jul;19(4):466-70.
Aortic valve calcification (AVC), which has been confirmed to be associated with various risk factors of cardiac disease, is common in the elderly and associated with increased cardiovascular mortality. It has been hypothesized that AVC is associated with coronary atherosclerotic disease, and its severity.
Between July 2007 and November 2007, a total of 235 patients with chest pain or chest distress were admitted to the authors' institution for coronary angiography. The severity of coronary atherosclerotic disease (CAD) was evaluated by the Gensini score, the number of stenosed vessels, and the prevalence of total occlusion. All patients underwent transthoracic echocardiography to detect AVC.
Patients with CAD had a higher prevalence of AVC than those without CAD (44% versus 26%, p = 0.005). Likewise, the prevalence of AVC was significantly higher in patients with a higher Gensini score than in those with a lower score. Patients with AVC had a higher prevalence of CAD, and higher Gensini scores and numbers of stenosed coronary arteries, even after stratification by age (65 years). On multivariable logistic regression analysis for CAD, the odds ratio (OR) of AVC was 2.315 (95% confidence interval (CI): 1.158-4.629, p = 0.018); this value was higher than that for total cholesterol (OR = 1.637, p = 0.008), lipoprotein-a (OR = 1.003, p = 0.015) and fibrinogen (OR = 1.009, p = 0.006), and marginally less than that for male gender (OR = 2.665, p = 0.005).
Patients with AVC had a higher prevalence and greater severity of CAD.
主动脉瓣钙化（AVC）在老年人中较为常见，且与心血管疾病死亡率增加相关，已证实其与多种心脏疾病风险因素有关。据推测，AVC与冠状动脉粥样硬化疾病及其严重程度相关。
2007年7月至2007年11月期间，共有235例胸痛或胸部不适患者入住作者所在机构接受冠状动脉造影。通过Gensini评分、狭窄血管数量和完全闭塞患病率评估冠状动脉粥样硬化疾病（CAD）的严重程度。所有患者均接受经胸超声心动图检查以检测AVC。
CAD患者的AVC患病率高于无CAD患者（44%对26%，p = 0.005）。同样，Gensini评分较高的患者中AVC患病率显著高于评分较低的患者。即使按年龄（65岁）分层后，AVC患者的CAD患病率、Gensini评分和狭窄冠状动脉数量也更高。在对CAD进行多变量逻辑回归分析时，AVC的优势比（OR）为2.315（95%置信区间（CI）：1.158 - 4.629，p = 0.018）；该值高于总胆固醇（OR = 1.637，p = 0.008）、脂蛋白-a（OR = 1.003，p = 0.015）和纤维蛋白原（OR = 1.009，p = 0.006），略低于男性（OR = 2.665，p = 0.005）。
AVC患者的CAD患病率更高且病情更严重。
