环氧化酶-2、p53 和葡萄糖转运蛋白-1 作为胆囊癌发生过程中恶性肿瘤的预测因子。
Cyclooxygenase-2, p53 and glucose transporter-1 as predictors of malignancy in the development of gallbladder carcinomas.
机构信息
Institute of Histology & Embryology, Faculty of Medicine, University of Ljubljana, Korytkova 2, SI-1000 Ljubljana, Slovenia.
出版信息
Bosn J Basic Med Sci. 2010 Aug;10(3):192-6. doi: 10.17305/bjbms.2010.2684.
Abstract
Gallbladder carcinoma is the fifth most common malignancy of the gastrointestinal tract. The absolute characteristics of the disease are the high mortality rate due to the late discovery of a tumor and the low therapeutic possibilities except by surgical intervention. In oncology we can predict the outcome of the disease with a combination of classical standard clinico/pathological parameters (stage of the tumors, differentiation) and the intrinsic genetic and biochemical properties of the tumor. Such intrinzic properties of the tumors that are connected with the outcome of the disease are the denominators (markers). The author searched extensively for the expression and influence of 3 markers included in chronic inflammation and early carcinogenesis, cell cycle regulation and tissue hypoxia: cyclooxygenase-2 (COX-2), p53 gene and glucose transporter-1 protein (GLUT-1). The author discusses their possible role in the development as well as fighting this disease, if specific medications targeting them were available.
摘要
胆囊癌是消化道第五大常见恶性肿瘤。该疾病的绝对特征是由于肿瘤的发现较晚，死亡率高，除手术干预外，治疗可能性低。在肿瘤学中，我们可以通过结合经典的标准临床/病理参数（肿瘤分期、分化）和肿瘤的内在遗传和生化特性来预测疾病的结局。与疾病结局相关的肿瘤内在特性是标志（marker）。作者广泛研究了包括慢性炎症和早期癌变、细胞周期调节和组织缺氧在内的 3 个标志物的表达和影响：环氧合酶-2（COX-2）、p53 基因和葡萄糖转运蛋白-1 蛋白（GLUT-1）。作者讨论了它们在疾病发展中的可能作用，如果有针对它们的特定药物，也讨论了它们在对抗这种疾病中的作用。
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