口服与舌下含服600微克米索前列醇治疗不全流产的对比研究。
Comparative study between oral and sublingual 600 µg misoprostol for the treatment of incomplete abortion.
作者信息
Paritakul Panwara, Phupong Vorapong
机构信息
Department of Obstetrics and Gynecology, Faculty of Medicine, Chulalongkorn University, Bangkok, Thailand.
出版信息
J Obstet Gynaecol Res. 2010 Oct;36(5):978-83. doi: 10.1111/j.1447-0756.2010.01264.x. Epub 2010 Sep 16.
AIM
To evaluate and compare effectiveness, side effects and patient acceptability between oral and sublingual 600 µg misoprostol for the treatment of incomplete abortion.
METHODS
A randomized controlled trial was conducted. Pregnant women of less than 14 weeks gestation, diagnosed with incomplete abortion, were randomly assigned to receive 600 µg misoprostol orally or sublingually. The patients were evaluated at 48 h after drug administration for complete abortion.
RESULTS
A total of 64 women were recruited to the study (32 in the oral group and 32 in the sublingual group). The complete abortion rate was not statistically different between oral and sublingual groups (87.5% versus 84.4%, P > 0.05). There was no statistical difference in side effects and satisfaction rate. Fever/chills were the most common side effects.
CONCLUSION
Both sublingual and oral 600 µg misoprostol are useful for the management of incomplete abortion. Side effects and satisfaction rates are not different. Thus, these methods may be used as alternative treatments of incomplete abortion.
目的
评估并比较口服和舌下含服600微克米索前列醇治疗不全流产的有效性、副作用及患者可接受性。
方法
进行了一项随机对照试验。将诊断为不全流产、孕周小于14周的孕妇随机分为口服或舌下含服600微克米索前列醇组。给药48小时后评估患者的完全流产情况。
结果
共有64名女性纳入研究（口服组32名，舌下含服组32名）。口服组和舌下含服组的完全流产率无统计学差异（87.5%对84.4%，P>0.05）。副作用和满意率无统计学差异。发热/寒战是最常见的副作用。
结论
舌下含服和口服600微克米索前列醇均对不全流产的治疗有效。副作用和满意率无差异。因此，这些方法可作为不全流产的替代治疗方法。
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