Neuroscience Research Institute, Gachon University of Medicine and Science, Namdong-Gu, Incheon, South Korea.
J Nucl Med. 2010 Oct;51(10):1545-8. doi: 10.2967/jnumed.110.076182. Epub 2010 Sep 16.
The hippocampus is one of the best-known neural structures in the brain and has been of interest in observing the substructures and their metabolic functions. However, it has been difficult to distinguish its substructures and functions in vivo because of its small size.
(18)F-FDG PET and high-resolution MRI of the hippocampus were performed on 5 healthy subjects using a PET/MRI system. The metabolism of each hippocampal substructure was measured in vivo on the basis of the MR images.
The dentate gyrus and cornu ammonis 4 showed the highest glucose uptake in the healthy subjects.
Measuring glucose metabolism in the substructures of the hippocampus could provide a new tool for the future investigation of related brain diseases or functional studies, such as Alzheimer disease or memory and learning studies.
海马体是大脑中最著名的神经结构之一，其亚结构及其代谢功能一直是观察的重点。然而，由于其体积较小，很难在体内区分其亚结构和功能。
使用 PET/MRI 系统对 5 名健康受试者进行（18）F-FDG PET 和海马体高分辨率 MRI 检查。根据 MRI 图像，在体内测量每个海马体亚结构的代谢情况。
健康受试者的齿状回和角回 4 显示出最高的葡萄糖摄取。
测量海马体亚结构的葡萄糖代谢可以为未来研究相关脑部疾病或功能研究（如阿尔茨海默病或记忆和学习研究）提供新的工具。
