Watanabe Masanari, Sano Hiroyuki, Tomita Katsuyuki, Yamasaki Akira, Kurai Jun, Hasegawa Yasuyuki, Igishi Tadashi, Okazaki Ryota, Tohda Yuji, Burioka Naoto, Shimizu Eiji
Division of Respirology and Rheumatology, Faculty of Medicine, Tottori University, Tottori, Japan.
J Med Invest. 2010 Aug;57(3-4):260-9. doi: 10.2152/jmi.57.260.
Salivary pH is associated with esophageal acid reflux and neutralization of esophageal acid. In this study, we assessed the association between nocturnal decline of salivary pH and airway hyperresponsiveness. Salivary pH was serially assessed in 9 patients with mild asthma (7 men and 2 women; mean age 33.3 years; mean %predicted FEV(1.0) 89.4%) and 10 healthy volunteers (6 men and 4 women; mean age 31.2 years) using a pH indicator tape. The buffering capacity of saliva was defined as the median effective dose (ED(50)) for acidification of saliva with 0.01 N HCl, and airway responsiveness was defined as the dose of methacholine producing a 35% fall in Grs (PD(35)-Grs). There was a significant correlation between the values obtained from the pH indicator tape and those obtained from the electrometric pH meter. Using the indicator tape for sequential monitoring, we observed a nocturnal fall (ΔpH) in salivary pH in all subjects. A significant correlation was found between airway hyperresponsiveness (PD(35)-Grs) and either ΔpH or ED(50) in mildly asthmatic patients. Vagal reflux dysfunction might contribute to nocturnal salivary pH as well as to airway hyperresponsiveness in mild asthmatics.
唾液pH值与食管酸反流及食管酸中和有关。在本研究中，我们评估了唾液pH值夜间下降与气道高反应性之间的关联。使用pH试纸对9例轻度哮喘患者（7例男性，2例女性；平均年龄33.3岁；平均预测FEV(1.0)百分比为89.4%）和10名健康志愿者（6例男性，4例女性；平均年龄31.2岁）的唾液pH值进行了连续评估。唾液的缓冲能力定义为用0.01N HCl使唾液酸化的半数有效剂量（ED(50)），气道反应性定义为使Grs下降35%的乙酰甲胆碱剂量（PD(35)-Grs）。pH试纸测得的值与电测pH计测得的值之间存在显著相关性。通过使用试纸进行连续监测，我们观察到所有受试者唾液pH值夜间均有下降（ΔpH）。在轻度哮喘患者中，气道高反应性（PD(35)-Grs）与ΔpH或ED(50)之间存在显著相关性。迷走神经反流功能障碍可能导致轻度哮喘患者夜间唾液pH值下降以及气道高反应性。
