Hegde Mithra N, Malhotra Amit, Hegde Nidarsh D
Department of Conservative Dentistry and Endodontics, A.B. Shetty Memorial Institute of Dental Sciences, Nitte University, Derelakatte, Mangalore, India.
Department of Oral and Maxillofacial Surgery, A.B. Shetty Memorial Institute of Dental Sciences, Nitte University, Derelakatte, Mangalore, India.
Dent Res J (Isfahan). 2013 Nov;10(6):772-6.
Human immunodeficiency virus (HIV) causes severe immunosuppression due to progressive decrease in the CD4 T lymphocyte cells during the course of the disease and this affects all the body systems including glandular secretions. A number of lesions affecting the salivary glands have been noted in HIV infection. The objective of this study was to evaluate the salivary pH and the buffering capacity in HIV positive individuals and comparing it with the HIV negative healthy individuals.
The study was carried out on 200 HIV positive subjects aged 20-40 years, divided into two groups on the basis of CD4 count and 100 HIV negative healthy individuals as control group. Both unstimulated and stimulated saliva were collected and the pH and buffering capacity ascertained using the saliva check kit. (GC Asia Dental Pvt. Ltd., Singapore, 508724).
All the three groups were compared using the ANOVA and it was found there was highly significant decrease in pH and buffering capacity with increase in immunosuppression. The intergroup comparison was carried out using the Tukey honestly significant difference (HSD) and the Chi square test. Group 1; CD4 count <200 and Group 2, CD4 count >200 showed a significant decrease in unstimulated salivary flow, stimulated salivary flow, and pH in comparison to HIV negative individuals; however, change in buffering capacity in Group 2 was not significant.
There is a decrease in pH and buffering capacity in HIV infected patients. This decrease may be one of the factors responsible for increased caries in HIV infected population.
人类免疫缺陷病毒（HIV）在疾病过程中会导致CD4 T淋巴细胞数量逐渐减少，从而引起严重的免疫抑制，这会影响包括腺体分泌在内的所有身体系统。在HIV感染中已发现一些影响唾液腺的病变。本研究的目的是评估HIV阳性个体的唾液pH值和缓冲能力，并将其与HIV阴性健康个体进行比较。
该研究对200名年龄在20至40岁的HIV阳性受试者进行，根据CD4计数分为两组，并以100名HIV阴性健康个体作为对照组。收集未刺激和刺激后的唾液，并使用唾液检测试剂盒（新加坡GC亚洲牙科私人有限公司，508724）确定pH值和缓冲能力。
使用方差分析对所有三组进行比较，发现随着免疫抑制的增加，pH值和缓冲能力显著降低。使用Tukey真实显著差异（HSD）和卡方检验进行组间比较。第1组，CD4计数<200；第2组，CD4计数>200，与HIV阴性个体相比，未刺激唾液流量、刺激唾液流量和pH值均显著降低；然而，第2组缓冲能力的变化不显著。
HIV感染患者的pH值和缓冲能力降低。这种降低可能是导致HIV感染人群龋齿增加的因素之一。
