Tindall R S, Willerson J
Arch Intern Med. 1978 Jul;138(7):1168-9.
Phenytoin sodium intoxication of subacute onset may occur in cases of nonepileptic patients who receive phenytoin for suppression of cardiac arrhythmias. The case reported here is of a syndrome that consisted of dementia, cerebellar dysfunction, and peripheral neuropathy. Withdrawal of phenytoin was followed by a slow improvement in the syndrome. Awareness of the features of subacute phenytoin intoxication in cardiac patients is important because this entity may mimic cerebrovascular disease. Periodic monitoring of serum phenytoin concentrations is advisable.
亚急性起病的苯妥英钠中毒可能发生在接受苯妥英治疗以抑制心律失常的非癫痫患者中。本文报道的病例是一种由痴呆、小脑功能障碍和周围神经病变组成的综合征。停用苯妥英后，该综合征逐渐改善。认识到心脏病患者中亚急性苯妥英中毒的特征很重要，因为这种情况可能会模仿脑血管疾病。建议定期监测血清苯妥英浓度。
