Post-graduate Program in Cardiology, Faculty of Medicine, Federal University of Rio Grande do Sul, Rua Ramiro Barcelos 2350, CEP 90035-003 Porto Alegre, RS, Brazil.
Inflamm Res. 2011 Feb;60(2):137-42. doi: 10.1007/s00011-010-0247-8. Epub 2010 Sep 17.
To evaluate the association between plasma myeloperoxidase (MPO) levels and angiographic severity of coronary atherosclerotic lesions in patients with non-ST elevation acute coronary syndrome (ACS).
This cross-sectional study examined high-risk ACS patients who underwent coronary angiography within 72 h of the onset of symptoms by measuring their plasma MPO levels after sheath insertion. Gensini score was used to evaluate angiographic severity of coronary artery disease.
A total of 48 patients were included in the study. Median MPO levels and Gensini scores were 6.9 ng/mL (4.4-73.5 ng/mL) and 10 (0-87.5), respectively. Spearman's correlation coefficient did not show a significant association between MPO levels and Gensini scores (r (s) = 0.2; p = 0.177). There was no correlation between MPO and age, hypertension, diabetes, leukocyte count, troponin I, CK-MB ≥ 2 × ULN (upper limit of normal), TIMI risk score ≥ 4 and Gensini score in the multivariate analysis.
Our findings indicate that MPO expression is not associated with anatomical severity of coronary lesions in ACS.
评估非 ST 段抬高型急性冠状动脉综合征（ACS）患者血浆髓过氧化物酶（MPO）水平与冠状动脉粥样硬化病变血管造影严重程度之间的关系。
本横断面研究通过测量发病后 72 小时内行冠状动脉造影患者的血浆 MPO 水平，评估了高危 ACS 患者的 MPO 水平。采用 Gensini 评分评估冠状动脉疾病的血管造影严重程度。
本研究共纳入 48 例患者。MPO 水平和 Gensini 评分的中位数分别为 6.9ng/mL（4.4-73.5ng/mL）和 10（0-87.5）。Spearman 相关系数分析未显示 MPO 水平与 Gensini 评分之间存在显著相关性（r（s）=0.2；p=0.177）。在多变量分析中，MPO 与年龄、高血压、糖尿病、白细胞计数、肌钙蛋白 I、CK-MB≥2×ULN（正常值上限）、TIMI 风险评分≥4 和 Gensini 评分之间均无相关性。
我们的研究结果表明，MPO 表达与 ACS 患者冠状动脉病变的解剖严重程度无关。
