Lönroth H, Granerus G, Rosengren E, Lundell L
Department of Surgery, Sahlgren's Hospital, Gothenburg, Sweden.
Scand J Clin Lab Invest. 1990 Dec;50(8):899-906. doi: 10.3109/00365519009104959.
The importance of the stomach in the magnitude of excreted amounts of the major histamine metabolite in the urine was studied during total parenteral nutrition in five patients before and after total gastrectomy. In all subjects, a reduction in the 24-h urinary excretion of methylimidazoleacetic acid was observed. No corresponding effect was seen after an operation because of abdominal aortic aneurysm. In patients with duodenal ulcer disease and those submitted to a cholecystectomy because of cholecystolithiasis, we studied the catabolism of histamine in the stomach by injecting 14C-histamine directly into the portal vein and, simultaneously, 3H-histamine intra-arterially to the corpus fundus region of the stomach and subsequently determining the urinary excretion of 14C. 3H-histamine and their basic and acid metabolites, respectively. We found no apparent difference in the pattern of excreted 14C and 3H metabolites between the two patients groups, indicating that the catabolism of histamine in the stomach of patients with duodenal ulcer disease is similar to that in 'healthy' controls.
在五名患者全胃切除术前和术后的全胃肠外营养期间，研究了胃在尿中主要组胺代谢产物排泄量大小方面的重要性。在所有受试者中，均观察到甲基咪唑乙酸的24小时尿排泄量减少。因腹主动脉瘤进行手术后未观察到相应影响。在患有十二指肠溃疡疾病的患者以及因胆囊结石接受胆囊切除术的患者中，我们通过将14C-组胺直接注入门静脉，同时将3H-组胺动脉内注入胃体底部区域，随后分别测定14C、3H-组胺及其碱性和酸性代谢产物的尿排泄量，研究了胃中组胺的分解代谢。我们发现两组患者之间14C和3H代谢产物的排泄模式没有明显差异，这表明十二指肠溃疡疾病患者胃中组胺的分解代谢与“健康”对照组相似。
