Department of Otolaryngology, Ajou University School of Medicine, Suwon, Korea.
Head Neck. 2010 Dec;32(12):1655-64. doi: 10.1002/hed.21383.
Hepatocyte growth factor (HGF) can promote proliferation, invasion, and angiogenesis in various tumor cells. However, the prognosis according to expression of HGF/c-Met has not been reported in patients with squamous cell carcinoma of the oral tongue (SCCOT).
Tumors from 61 patients with SCCOT were evaluated for the expression of HGF and c-Met by immunohistochemistry. For Western blot, we used fresh normal and cancer tissues from 3 patients with SCCOT.
The positive rates of HGF and c-Met immunostaining in SCCOT were 57.3% and 54.1%, respectively. The c-Met staining was significantly correlated with lymph node metastasis (p = .005), tumor classification (p = .004), and recurrence (p = .018). Survival was significantly affected in patients with positive c-Met expression (p = .003). HGF and c-Met were strongly expressed in cancer tissues on Western blot.
The c-Met expression may play an important role in the progression and the survival outcome of patients with SCCOT.
肝细胞生长因子 (HGF) 可促进多种肿瘤细胞的增殖、侵袭和血管生成。然而，在口腔舌鳞癌（SCCOT）患者中，根据 HGF/c-Met 的表达情况进行预后评估的报道尚不多见。
通过免疫组织化学方法评估 61 例 SCCOT 患者肿瘤中 HGF 和 c-Met 的表达情况。对于 Western blot，我们使用了 3 例 SCCOT 患者的新鲜正常和癌组织。
SCCOT 中 HGF 和 c-Met 免疫染色的阳性率分别为 57.3%和 54.1%。c-Met 染色与淋巴结转移（p=0.005）、肿瘤分级（p=0.004）和复发（p=0.018）显著相关。c-Met 表达阳性的患者生存显著受到影响（p=0.003）。Western blot 显示 HGF 和 c-Met 在癌组织中均强烈表达。
c-Met 表达可能在 SCCOT 患者的进展和生存结果中发挥重要作用。
