c-Met 表达可作为口腔舌癌患者生存结局的一个指标。

c-Met expression as an indicator of survival outcome in patients with oral tongue carcinoma.

机构信息

Department of Otolaryngology, Ajou University School of Medicine, Suwon, Korea.

出版信息

Head Neck. 2010 Dec;32(12):1655-64. doi: 10.1002/hed.21383.

DOI:10.1002/hed.21383

PMID:20848408

Abstract

BACKGROUND

Hepatocyte growth factor (HGF) can promote proliferation, invasion, and angiogenesis in various tumor cells. However, the prognosis according to expression of HGF/c-Met has not been reported in patients with squamous cell carcinoma of the oral tongue (SCCOT).

METHODS

Tumors from 61 patients with SCCOT were evaluated for the expression of HGF and c-Met by immunohistochemistry. For Western blot, we used fresh normal and cancer tissues from 3 patients with SCCOT.

RESULTS

The positive rates of HGF and c-Met immunostaining in SCCOT were 57.3% and 54.1%, respectively. The c-Met staining was significantly correlated with lymph node metastasis (p = .005), tumor classification (p = .004), and recurrence (p = .018). Survival was significantly affected in patients with positive c-Met expression (p = .003). HGF and c-Met were strongly expressed in cancer tissues on Western blot.

CONCLUSION

The c-Met expression may play an important role in the progression and the survival outcome of patients with SCCOT.

摘要

背景

肝细胞生长因子 (HGF) 可促进多种肿瘤细胞的增殖、侵袭和血管生成。然而，在口腔舌鳞癌（SCCOT）患者中，根据 HGF/c-Met 的表达情况进行预后评估的报道尚不多见。

方法

通过免疫组织化学方法评估 61 例 SCCOT 患者肿瘤中 HGF 和 c-Met 的表达情况。对于 Western blot，我们使用了 3 例 SCCOT 患者的新鲜正常和癌组织。

结果

SCCOT 中 HGF 和 c-Met 免疫染色的阳性率分别为 57.3%和 54.1%。c-Met 染色与淋巴结转移（p=0.005）、肿瘤分级（p=0.004）和复发（p=0.018）显著相关。c-Met 表达阳性的患者生存显著受到影响（p=0.003）。Western blot 显示 HGF 和 c-Met 在癌组织中均强烈表达。