Department of Pathological Physiology, Faculty of Medicine, Masaryk University, Kamenice 5, 625 00, Brno, Czech Republic.
Department of Physiology, Faculty of Medicine, Masaryk University, Kamenice 5, 625 00, Brno, Czech Republic.
Sci Rep. 2018 Jul 10;8(1):10370. doi: 10.1038/s41598-018-28672-8.
This meta-analysis aims to evaluate the effects of high c-Met levels in head and neck squamous cell carcinomas (HNSCC) on survival and clinicopathological features. Publications concerned with the clinical significance of c-Met protein expression in HNSCC were identified from the Scopus and Web of Science database searches. To elucidate the relationship between c-Met expression and clinical outcomes, a meta-analysis of the selected articles was conducted. Seventeen publications involving a total of 1724 patients met the inclusion criteria. c-Met overexpression was significantly correlated with poor overall survival (hazard ratio (HR) = 2.19, 95% confidence interval (CI) = 1.55-3.10). c-Met immunohistochemical staining positivity was also associated with worse relapse-free survival (HR = 1.64, 95% CI = 1.24-2.17) and presence of regional lymph node metastases (odds ratio (OR) = 1.76, 95% CI = 1.26-2.45). High levels of c-Met expression in HNSCC predict unfavorable prognosis associated with common clinicopathological features.
本荟萃分析旨在评估头颈部鳞状细胞癌（HNSCC）中高 c-Met 水平对生存和临床病理特征的影响。从 Scopus 和 Web of Science 数据库搜索中确定了与 HNSCC 中 c-Met 蛋白表达的临床意义相关的出版物。为了阐明 c-Met 表达与临床结局之间的关系，对选定的文章进行了荟萃分析。有 17 篇出版物共涉及 1724 名患者符合纳入标准。c-Met 过表达与总生存期不良显著相关（风险比（HR）=2.19，95%置信区间（CI）=1.55-3.10）。c-Met 免疫组织化学染色阳性也与无复发生存期更差相关（HR=1.64，95%CI=1.24-2.17）和区域淋巴结转移存在相关（比值比（OR）=1.76，95%CI=1.26-2.45）。HNSCC 中 c-Met 的高表达预示着与常见临床病理特征相关的不良预后。
