喉鳞癌患者气道阻塞的影响和处理。

Impact and management of airway obstruction in patients with squamous cell carcinoma of the larynx.

机构信息

Department of Otolaryngology, Taipei Veterans General Hospital and National Yang-Ming University, Taipei, Taiwan, Republic of China.

出版信息

Head Neck. 2011 Jan;33(1):98-102. doi: 10.1002/hed.21401.

DOI:10.1002/hed.21401

PMID:20848422

Abstract

BACKGROUND

We compared postoperative complications and oncologic results after laryngectomy of patients with laryngeal squamous cell carcinoma (SCC), with and without airway obstruction.

METHODS

We retrospectively reviewed the medical records of 544 patients with laryngeal SCC between 1990 and 2000. Of 175 advanced cases receiving total laryngectomy, 32 initially presented with upper airway obstruction.

RESULTS

Postoperative complications after laryngectomy did not differ significantly between patients with and without airway obstruction (36% vs 28%; p = .353). Although patients with airway obstruction had more T4 (81% vs 42%; p < .001) and stage IV disease (82% vs 48%; p = .0004), tumor recurrence rates did not increase (21% vs 29%; p = .374). Five-year overall (52% vs 60%; p = .251), disease-specific (73% vs 70%; p = .982), and relapse-free (72% vs 68%; p = .982) survival did not differ significantly between groups.

CONCLUSION

After appropriate management of airway obstruction, the postoperative complications and oncologic results were similar to those without airway obstruction.

摘要

背景

我们比较了伴有和不伴有气道阻塞的喉鳞状细胞癌（SCC）患者行喉切除术的术后并发症和肿瘤学结果。

方法

我们回顾性分析了 1990 年至 2000 年间 544 例喉 SCC 患者的病历。在接受全喉切除术的 175 例晚期病例中，有 32 例最初表现为上气道阻塞。

结果

喉切除术的术后并发症在伴有和不伴有气道阻塞的患者之间无显著差异（36%比 28%；p =.353）。尽管伴有气道阻塞的患者 T4 期（81%比 42%；p <.001）和 IV 期疾病（82%比 48%；p =.0004）更多，但肿瘤复发率并未增加（21%比 29%；p =.374）。两组患者的 5 年总生存率（52%比 60%；p =.251）、疾病特异性生存率（73%比 70%；p =.982）和无复发生存率（72%比 68%；p =.982）均无显著差异。