鼻腔鼻窦鳞状细胞癌的基因组分析。
Genomic profiling of sinonasal squamous cell carcinoma.
机构信息
Department of Otolaryngology, Instituto Universitario de Oncología del Principado de Asturias, Hospital Universitario Central de Asturias, Oviedo, Asturias, Spain.
出版信息
Head Neck. 2011 Feb;33(2):145-53. doi: 10.1002/hed.21417.
BACKGROUND
Sinonasal squamous cell carcinomas (SCCs) are rare tumors with no etiologic link to tobacco and alcohol, as opposed to other SCCs of the head and neck (HNSCC). Little is known about the genetic changes in sinonasal SCC.
METHODS
DNA copy number changes of sinonasal SCC were analyzed by multiplex ligation-dependent probe amplification (MLPA) and microarray comparative genomic hybridization (maCGH), and results were related to clinicopathologic features.
RESULTS
Copy number losses most frequently included genes at 9p21, 13q14, 17p13, 17q21, and 18q11. Frequent gains were observed on 8q24, 11q13, 17q12, 19p13, and 20q11-q13.
CONCLUSION
The genomic profile of sinonasal SCC showed a number of chromosomal regions with copy number changes similar to those known in HNSCC, in spite of the differences in etiology.
背景
与头颈部其他鳞状细胞癌（SCC）不同，鼻窦 SCC 是一种罕见的肿瘤，其发生与烟草和酒精无关。人们对鼻窦 SCC 的遗传变化知之甚少。
方法
采用多重连接依赖性探针扩增（MLPA）和微阵列比较基因组杂交（maCGH）分析鼻窦 SCC 的 DNA 拷贝数变化，并将结果与临床病理特征相关联。
结果
拷贝数缺失最常包括 9p21、13q14、17p13、17q21 和 18q11 上的基因。经常观察到 8q24、11q13、17q12、19p13 和 20q11-q13 的增益。
结论
尽管病因不同，但鼻窦 SCC 的基因组图谱显示出许多染色体区域的拷贝数变化与头颈部 SCC 中已知的相似。
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