Department of Medicine, University College London, London, UK.
Inflamm Bowel Dis. 2010 Nov;16(11):1984-92. doi: 10.1002/ibd.21280.
Crohn's disease and ulcerative colitis are idiopathic chronic inflammatory diseases that primarily affect the gastrointestinal tract. The underlying causes remain poorly understood, but there is a growing body of evidence advocating a likely primary pathogenic role for immunodeficiency in the development of Crohn's lesions. Concordantly, a number of congenital immunodeficiencies disrupting the cellular innate immune system strongly predispose to noninfectious, Crohn's-like inflammatory bowel disease. There are case reports and series suggesting that the same may be true for some of the congenital adaptive and complement immunodeficiencies. This review considers and critiques these potential associations.
克罗恩病和溃疡性结肠炎是特发性慢性炎症性疾病，主要影响胃肠道。其根本原因仍不清楚，但越来越多的证据表明，免疫缺陷可能在克罗恩病病变的发展中起主要致病作用。相应地，一些破坏细胞固有免疫系统的先天性免疫缺陷使非传染性、类似克罗恩病的炎症性肠病的易感性大大增加。有病例报告和系列研究表明，一些先天性适应性和补体免疫缺陷也可能存在同样的情况。本文对这些潜在的关联进行了考虑和评估。
