Martínez-Augustin Olga, Rivero-Gutiérrez Belén, Mascaraque Cristina, Sánchez de Medina Fermín
Department of Biochemistry and Molecular Biology 2, CIBERehd, University of Granada, Instituto de Investigación Biosanitaria ibs, Granada 18071, Spain.
Department of Pharmacology, CIBERehd, University of Granada, Instituto de Investigación Biosanitaria ibs, Granada 18071, Spain.
Int J Mol Sci. 2014 Dec 9;15(12):22857-73. doi: 10.3390/ijms151222857.
A wide range of food-derived bioactive peptides have been shown to exert health-promoting actions and are therefore considered functional foods or nutraceuticals. Some of these actions are related to the maintenance, reinforcement or repairment of the intestinal barrier function (IBF) whose role is to selectively allow the absorption of water, nutrients and ions while preventing the influx of microorganisms from the intestinal lumen. Alterations in the IBF have been related to many disorders, such as inflammatory bowel disease or metabolic syndrome. Components of IBF are the intestinal epithelium, the mucus layer, secretory immunoglobulin A and cells of the innate and adaptive immune systems. Here we review the effects of food derived bioactive peptides on these IBF components. In vitro and in vivo effects, both in healthy and disease states, have been reviewed. Although limited, the available information indicates a potential for food-derived peptides to modify IBF and to contribute to disease treatment, but further research is needed to better isolate responsible peptides, and to help define their mode of action.
多种源自食物的生物活性肽已被证明具有促进健康的作用，因此被视为功能性食品或营养保健品。其中一些作用与肠道屏障功能（IBF）的维持、强化或修复有关，肠道屏障功能的作用是选择性地允许水、营养物质和离子的吸收，同时防止微生物从肠腔流入。IBF的改变与许多疾病有关，如炎症性肠病或代谢综合征。IBF的组成部分包括肠上皮、黏液层、分泌型免疫球蛋白A以及先天和适应性免疫系统的细胞。在此，我们综述了源自食物的生物活性肽对这些IBF组成部分的影响。本文回顾了在健康和疾病状态下的体外和体内效应。尽管现有信息有限，但表明源自食物的肽具有改变IBF并有助于疾病治疗的潜力，但需要进一步研究以更好地分离出起作用的肽，并帮助确定其作用方式。
