Zhu Hong-Yuan, Xiao Jin, Liu Yu-Jie, Cui Yan, Ye Li-Ming, Yin Hai-Lin
School of Life Science, Sichuan University, Chengdu 610064, China.
Sichuan Da Xue Xue Bao Yi Xue Ban. 2010 Jul;41(4):660-3.
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To analysis the metabonome characteristics of the urine of MSU crystal-induced acute gouty arthritis rats by the method of metabolomics.
Based on the method of metabolomics, which applies LC/MS as data acquisition platform, incorporating with the means of stoechiometry such as principal component analysis, we analyzed the metabonome difference between the urine of acute gouty arthritis rats and that of normal rats.
Compare with control group, the metabolism status of acute gouty arthritis model group deviated. After that, with the time lapsed, it retrieved gradually to the incipient metabolism status. The variation of metabolism locus of rats measured by the methods of metabolomics properly reflects the genesis, development, and recuperation course of acute gouty arthritis.
The whole metabolism status of rat model is able to be presented finely with the method of metabolomics. The metabolomics study could offer a satisfactory research approach to acute gouty arthritis.
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采用代谢组学方法分析尿酸钠晶体诱导的急性痛风性关节炎大鼠尿液的代谢组特征。
基于以液相色谱/质谱联用为数据采集平台的代谢组学方法，并结合主成分分析等化学计量学手段，分析急性痛风性关节炎大鼠与正常大鼠尿液的代谢组差异。
与对照组相比，急性痛风性关节炎模型组的代谢状态发生偏离。之后，随着时间推移，其逐渐恢复至初始代谢状态。采用代谢组学方法测定的大鼠代谢位点变化恰当地反映了急性痛风性关节炎的发生、发展及恢复过程。
代谢组学方法能够很好地呈现大鼠模型的整体代谢状态。代谢组学研究可为急性痛风性关节炎提供令人满意的研究途径。
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