Goloshchapov O A, Goldabin V I, Geller A L, Mashin A A
Ter Arkh. 1990;62(10):149-52.
As many as 98 patients suffering from essential hypertension (EH) were examined for the effects of verapamil and nifedipine. The hemodynamics and heart contractility were estimated by means of echocardiography on an "Aloka D-280" outfit (Japan). The following parameters of the cardio- and hemodynamics were computed: the stroke and minute blood volumes, cardiac index, mean velocity of ventricular evacuation, performance of the left heart, energy consumption by the myocardium, arterial pressure (systolic, diastolic and mean), total peripheral vascular resistance, ejection fraction, and the rate of circulatory shortening of myocardial fibers. Analysis of the effects of verapamil and nifedipine on the cardio- and hemodynamics in EH patients has demonstrated that in addition to their unidirectional action manifested by a steady hypotensive effect, the drugs under consideration produced an action of different directions as regards certain essential parameters in a considerable number of the patients.
对多达98名原发性高血压(EH)患者进行了维拉帕米和硝苯地平疗效的检查。借助“阿洛卡D - 280”设备(日本)通过超声心动图评估血流动力学和心脏收缩力。计算了以下心脏和血流动力学参数:每搏输出量和每分钟血流量、心脏指数、心室排空平均速度、左心功能、心肌能量消耗、动脉压(收缩压、舒张压和平均压)、总外周血管阻力、射血分数以及心肌纤维循环缩短率。对维拉帕米和硝苯地平对EH患者心脏和血流动力学影响的分析表明,除了通过稳定的降压作用表现出的单向作用外,在所研究的患者中,相当一部分患者的这些药物在某些关键参数方面产生了不同方向的作用。