Acharya Sourya, Shukla Samarth, Mahajan S N, Diwan S K
Dept. of Medicine, Dutta Meghe Institute of Medical Sciences, J. N. Medical College, Sawangi (Meghe), Wardha - 442004, Maharashtra.
J Assoc Physicians India. 2010 Mar;58:163-8.
Molecular mimicry is one mechanism by which infectious agents (or other exogenous substances) trigger an immune response against the host antigens. When a susceptible host acquires an infection with an organism that has antigens immunologically similar to the host antigens but differ sufficiently, to induce, an immune response when presented to T cells, results in loss of tolerance to host antigens. Further more there is development of a pathogen-specific immune response that cross-reacts with host structures to cause tissue damage and disease. Till date the advances in the research in molecular biology has documented evidence to suggest that molecular mimicry plays in important role in pathogenesis of a number of diseases. This review is a brief overview of some of these disorders.
分子模拟是感染因子（或其他外源性物质）引发针对宿主抗原的免疫反应的一种机制。当易感宿主感染一种具有与宿主抗原在免疫上相似但又有足够差异的抗原的生物体时，该抗原呈递给T细胞时会诱导免疫反应，导致对宿主抗原的耐受性丧失。此外，还会产生一种与宿主结构发生交叉反应的病原体特异性免疫反应，从而导致组织损伤和疾病。迄今为止，分子生物学研究的进展已记录证据表明分子模拟在多种疾病的发病机制中起重要作用。本综述简要概述了其中一些疾病。
