Bakr N I, El-Sawy E, Hamdy A F, Bakr M A
Dermatology and Andrology Department, Students' Hospital, Mansoura University, Mansoura, Egypt.
Transpl Infect Dis. 2011 Apr;13(2):131-5. doi: 10.1111/j.1399-3062.2010.00568.x. Epub 2010 Sep 16.
The risk of skin infections in renal transplant recipients (RTRs) has been described previously; however, it differs markedly by ethnic groups, skin type, and geographical location. We investigated the prevalence and nature of skin infections in a large series of RTRs in our locality in Egypt.
A total 302 RTRs (216 males and 86 females) were included in this study. They were screened for the presence of bacterial, fungal, and viral skin infections depending on clinical signs, Woods lamp examinations, culture, and biopsy if indicated. The patients were compared with 300 healthy controls matched for age and sex (200 males and 100 females).
We found 191 (63.25%) RTRs had some kind of skin infection. Folliculitis (10.3%), tinea versicolor (30.1%), dermatophytosis (19.5%), and onychomycosis (7.6%) were statistically significantly more common in RTRs compared with control subjects.
Our RTRs have higher prevalence rates of folliculitis and superficial fungal infections than the healthy population and they should be searched for in every patient with renal transplantation to ensure early treatment and avoid complications. Low-dose ketoconazole should be considered in renal transplant populations with high rates of superficial fungal infections, as it may reduce risk of such infections.
肾移植受者（RTRs）发生皮肤感染的风险此前已有描述；然而，其在不同种族、皮肤类型和地理位置之间存在显著差异。我们调查了埃及本地一大系列RTRs中皮肤感染的患病率及性质。
本研究共纳入302例RTRs（男性216例，女性86例）。根据临床体征、伍德灯检查、培养以及必要时的活检，对他们进行细菌、真菌和病毒皮肤感染筛查。将这些患者与300名年龄和性别匹配的健康对照者（男性200例，女性100例）进行比较。
我们发现191例（63.25%）RTRs患有某种皮肤感染。与对照者相比，RTRs中毛囊炎（10.3%）、花斑癣（30.1%）、皮肤癣菌病（19.5%）和甲癣（7.6%）在统计学上显著更为常见。
我们的RTRs中毛囊炎和浅表真菌感染的患病率高于健康人群，对于每一位肾移植患者都应进行检查，以确保早期治疗并避免并发症。对于浅表真菌感染率高的肾移植人群，应考虑使用低剂量酮康唑，因为它可能降低此类感染的风险。
