先天免疫与疫苗。

Innate immunity and vaccine.

机构信息

Department of Microbiology and Immunology, Hokkaido University Graduate School of Medicine, Kita-ku, Kita 15, Nishi 7, Sapporo 060-8638, Japan.

出版信息

Vaccine. 2010 Nov 23;28(50):8041-2. doi: 10.1016/j.vaccine.2010.09.023. Epub 2010 Sep 17.

DOI:10.1016/j.vaccine.2010.09.023

PMID:20849873

Abstract

Immune adjuvant is an artificial pathogen-associated molecular patterns (PAMP) for potentiating various immune responses. Vaccine represents one event that is capable of inducing immune response caused by antigen and PAMP stimuli, which act on antigen-presenting dendritic cells (mDCs). Here, we introduce the pathways by which CTL and NK cells are driven through mDC maturation in response to adjuvants.

摘要

免疫佐剂是一种人工病原体相关分子模式 (PAMP)，可增强各种免疫反应。疫苗是一种能够诱导抗原和 PAMP 刺激引起的免疫反应的事件，这些刺激作用于抗原呈递树突状细胞 (mDC)。在这里，我们介绍了 CTL 和 NK 细胞通过 mDC 成熟对佐剂产生反应的途径。