Department of Microbiology and Immunology, Hokkaido University Graduate School of Medicine, Kita-ku, Kita 15, Nishi 7, Sapporo 060-8638, Japan.
Vaccine. 2010 Nov 23;28(50):8041-2. doi: 10.1016/j.vaccine.2010.09.023. Epub 2010 Sep 17.
Immune adjuvant is an artificial pathogen-associated molecular patterns (PAMP) for potentiating various immune responses. Vaccine represents one event that is capable of inducing immune response caused by antigen and PAMP stimuli, which act on antigen-presenting dendritic cells (mDCs). Here, we introduce the pathways by which CTL and NK cells are driven through mDC maturation in response to adjuvants.
免疫佐剂是一种人工病原体相关分子模式 (PAMP)，可增强各种免疫反应。疫苗是一种能够诱导抗原和 PAMP 刺激引起的免疫反应的事件，这些刺激作用于抗原呈递树突状细胞 (mDC)。在这里，我们介绍了 CTL 和 NK 细胞通过 mDC 成熟对佐剂产生反应的途径。
