Shields J A, Shields C L
Ocular Oncology Service, Wills Eye Hospital, Thomas Jefferson University, Philadelphia, Pennsylvania 19107.
Trans Pa Acad Ophthalmol Otolaryngol. 1990;42:931-7.
Histiocytic tumors of the orbit comprise an unusual group of lesions characterized by the infiltration of the orbital tissues by xanthomatous cells. Recently, there have been a number of new observations regarding the various histiocytic tumors that can affect the orbit. The condition previously referred to as histiocytosis X is believed to represent a proliferation of Langerhans cells and the term Langerhans cell histiocytosis is often used instead of histiocytosis X. Juvenile xanthogranuloma has been demonstrated to affect the orbit without involving the skin or the iris. The Erdheim-Chester disease is a condition of adults characterized by infiltration of bone, retroperitoneum, heart, lungs and other tissues by xanthoma cells. This condition has recently been recognized to produce a classic ophthalmological picture of bilateral xanthelasmas and bilateral proptosis. The authors review their personal experience with several patients with histiocytic tumors of the orbit and stress the clinical spectrum of these conditions.
眼眶组织细胞性肿瘤是一组特殊的病变，其特征为眼眶组织被黄色瘤细胞浸润。近来，关于可累及眼眶的各种组织细胞性肿瘤有了一些新的观察结果。以前被称为组织细胞增多症X的疾病被认为是朗格汉斯细胞的增殖，现在常用朗格汉斯细胞组织细胞增多症这一术语来取代组织细胞增多症X。幼年性黄色肉芽肿已被证实可累及眼眶，而不涉及皮肤或虹膜。厄尔德海姆-切斯特病是一种成人疾病，其特征为黄色瘤细胞浸润骨骼、腹膜后、心脏、肺及其他组织。最近认识到这种疾病可产生双侧睑黄瘤和双侧眼球突出的典型眼科表现。作者回顾了他们对几名眼眶组织细胞性肿瘤患者的个人经验，并强调了这些疾病的临床谱。
