Skalli S, Ferreira E, Bussières J-F, Allenet B
Unité de Recherche en Pratique Pharmaceutique, Département de Pharmacie, Centre Hospitalier Universitaire Sainte-Justine, 3175 chemin de la Côte-Sainte-Catherine, Montréal H3T 1C5, Canada.
Ann Pharm Fr. 2010 Sep;68(5):269-74. doi: 10.1016/j.pharma.2010.04.005. Epub 2010 Jun 8.
Pregnant women are at increased risk of severe complications associated with H1N1 pandemic influenza. Fever and inflammatory syndrome associated with the infection may also be deleterious for the developing fetus. Therefore, early antiviral treatment is recommended. Oseltamivir and zanamivir are the two therapeutic options available indicated in the treatment of H1N1 influenza; however, limited data is published on their use during pregnancy and lactation. In this review, we will focus on the effects of H1N1 during pregnancy and on data safety of antivirals during pregnancy and lactation. Main health authorities recommendations for H1N1 influenza treatment of pregnant women will also be presented.
孕妇感染甲型H1N1流感大流行相关严重并发症的风险增加。感染相关的发热和炎症综合征也可能对发育中的胎儿有害。因此,建议尽早进行抗病毒治疗。奥司他韦和扎那米韦是治疗甲型H1N1流感的两种可用治疗选择;然而,关于它们在妊娠和哺乳期使用的数据有限。在本综述中,我们将重点关注甲型H1N1流感在孕期的影响以及抗病毒药物在妊娠和哺乳期的数据安全性。还将介绍主要卫生当局对孕妇甲型H1N1流感治疗的建议。