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叶状瓣悬带术治疗儿童二尖瓣和三尖瓣反流:一项病例对照研究的结果。

Leaflet suspension to the contralateral annulus to address restriction or tethering-induced mitral and tricuspid regurgitation in children: results of a case-control study.

机构信息

Division of Cardiovascular Surgery, Geneva University Hospitals, Geneva, Switzerland.

出版信息

J Thorac Cardiovasc Surg. 2010 Nov;140(5):1110-6. doi: 10.1016/j.jtcvs.2010.08.015. Epub 2010 Sep 17.

Abstract

OBJECTIVES

Acceptable coaptation cannot always be obtained using standard repair techniques. We assessed the safety and mid-term results using a novel technique to address leaflet retraction or tethering in children with type III mitral or tricuspid regurgitation as an addition to standard valve repair techniques.

METHODS

Forty children were included, 36 for the mitral valve and 4 for the tricuspid valve, with a mean age of 11.3 ± 3.9 years. A polypropylene suture was placed on the free edge of the retracted or tethered leaflet segment and anchored to the atrial side of the opposite annulus. This avoided valve replacement in all patients. An additional 40 children were matched for age, etiology, leaflet retraction or tethering, and surgery in which the suspension stitch was not used and constituted the control group.

RESULTS

The mean aortic crossclamp and cardiopulmonary bypass time was 36 ± 9 and 57 ± 9 minutes, respectively. No early or late deaths occurred. At discharge, no patient had more than mild regurgitation with a gradient of 4.4 ± 2.4 mm Hg in the mitral position and 2 ± 1.75 mm Hg in the tricuspid position. The results were not significantly different than those of the control group. During a follow-up of 37.7 ± 18.4 months, 3 patients required reoperation for mitral valve replacement in the suspension stitch group and 2 within the control group. At echocardiography of the remaining patients, the repair remained stable, with no suspension suture breakage.

CONCLUSIONS

This suspension technique improved coaptation and resulted in avoidance or delay of valve replacement in patients with type III regurgitation, with an acceptable transvalvular gradient in most patients that did not significantly increase with growth.

摘要

目的

使用标准修复技术通常无法获得可接受的对合。我们评估了一种新型技术的安全性和中期结果,该技术用于解决儿童三尖瓣或二尖瓣 III 型反流中的瓣叶回缩或牵带问题,作为标准瓣修复技术的补充。

方法

共纳入 40 例患儿,其中 36 例为二尖瓣,4 例为三尖瓣,平均年龄 11.3±3.9 岁。将聚丙烯缝线置于回缩或牵带的瓣叶段的游离缘上,并固定在对侧瓣环的心房侧。这避免了所有患者的瓣膜置换。另外 40 例患儿年龄、病因、瓣叶回缩或牵带以及未使用悬吊缝线的手术相匹配,构成对照组。

结果

平均主动脉阻断和体外循环时间分别为 36±9 分钟和 57±9 分钟。无早期或晚期死亡。出院时,无患者存在超过轻度反流,二尖瓣位置的梯度为 4.4±2.4mmHg,三尖瓣位置为 2±1.75mmHg。结果与对照组无显著差异。在 37.7±18.4 个月的随访中,悬吊缝线组 3 例患者因二尖瓣置换而需要再次手术,对照组 2 例。在其余患者的超声心动图检查中,修复保持稳定,无悬吊缝线断裂。

结论

这种悬吊技术改善了对合,避免或延迟了 III 型反流患者的瓣膜置换,大多数患者的跨瓣梯度可接受,且随着生长不会显著增加。

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