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二尖瓣手术患者中轻至中度功能性三尖瓣反流。

Mild-to-moderate functional tricuspid regurgitation in patients undergoing mitral valve surgery.

机构信息

Department of Thoracic and Cardiovascular Surgery, Asan Medical Center, University of Ulsan College of Medicine, Seoul, South Korea.

出版信息

J Thorac Cardiovasc Surg. 2013 Nov;146(5):1092-7. doi: 10.1016/j.jtcvs.2012.07.100. Epub 2012 Aug 31.

Abstract

OBJECTIVE

The decision to repair mild-to-moderate functional tricuspid regurgitation (TR) during mitral valve surgery remains controversial. We evaluated the effects of tricuspid valve (TV) repair for functional mild-to-moderate TR during mitral valve surgery.

METHODS

We enrolled 959 patients with mild-to-moderate functional TR who underwent mitral valve surgery with (repair group n = 431) or without (control group n = 528) concomitant TV repair from January 1994 to September 2010.

RESULTS

There were no significant differences in early mortality or major morbidity rates. Median follow-up was 64.8 months (range, 0.03-203.6 months). After adjustment for baseline characteristics using a propensity score adjustment model, the repair group had similar risks for TV reoperation (hazard ratio [HR], 0.46; 95% confidence interval [CI], 0.10-2.07; P = .31); congestive heart failure (HR, 1.12; 95% CI, 0.37-3.36; P = .84); death (HR, 1.41; 95% CI, 0.82-2.42; P = .22); and the composite of death, TV reoperation, and congestive heart failure (HR, 1.24; 95% CI, 0.76-2.03; P = .39) compared with the control group. On multivariate Cox-regression analysis, old age, atrial fibrillation without a Maze procedure, diabetes mellitus, chronic renal failure, poor left ventricular ejection fraction, and redo surgery emerged as significant independent risk factors for the composite outcome of death, TV reoperation, and congestive heart failure.

CONCLUSIONS

Early or late clinical benefits of concomitant TV repair for mild-to-moderate TR during mitral valve surgery were uncertain through a long-term follow-up of 959 patients. Several preoperative factors and the performance of Maze procedure for AF seem to be more important than TV repair in overall clinical outcomes.

摘要

目的

在二尖瓣手术中修复轻度至中度功能性三尖瓣反流(TR)的决策仍存在争议。我们评估了在二尖瓣手术中修复功能性轻度至中度 TR 的三尖瓣(TV)的效果。

方法

我们纳入了 1994 年 1 月至 2010 年 9 月期间接受二尖瓣手术且伴(修复组 n=431)或不伴(对照组 n=528)同期 TV 修复的 959 例轻度至中度功能性 TR 患者。

结果

两组早期死亡率或主要发病率无显著差异。中位随访时间为 64.8 个月(范围:0.03-203.6 个月)。使用倾向评分调整模型调整基线特征后,修复组 TV 再次手术的风险相似(风险比 [HR],0.46;95%置信区间 [CI],0.10-2.07;P=0.31);充血性心力衰竭(HR,1.12;95% CI,0.37-3.36;P=0.84);死亡(HR,1.41;95% CI,0.82-2.42;P=0.22);以及死亡、TV 再次手术和充血性心力衰竭的复合终点(HR,1.24;95% CI,0.76-2.03;P=0.39)与对照组相比。多变量 Cox 回归分析显示,年龄较大、无迷宫手术的心房颤动、糖尿病、慢性肾衰竭、左心室射血分数较差和再次手术是死亡、TV 再次手术和充血性心力衰竭复合终点的显著独立危险因素。

结论

通过对 959 例患者的长期随访,在二尖瓣手术中同时修复轻度至中度 TR 的 TV 并不能早期或晚期改善临床获益。几个术前因素和 AF 的迷宫手术似乎比 TV 修复更重要,对整体临床结局影响更大。

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