Department of Neurosurgery, Shanghai Jiaotong University School of Medicine, China.
Brain Res Bull. 2011 Jan 15;84(1):1-7. doi: 10.1016/j.brainresbull.2010.09.008. Epub 2010 Sep 17.
In response to injury, the function of the adult mammalian central nervous system (CNS) is repaired by angiogenesis and neurogenesis. The proliferation, differentiation and migration of the neural progenitor cells (NPCs) are regulated by several components of the vascular microenvironment within the neural stem cell niche. Vascular endothelial cells (VECs), which make up blood vessels, as well as extracellular components, affect neurogenesis directly via contacting with NPCs. Additionally, soluble factors from the vascular system that are released into the CNS enhance neurogenesis in the form of paracrine signaling. The purpose of this mini-review is to highlight the roles of the vascular microenvironment as a mediator in promoting neurogenesis.
针对损伤，成年哺乳动物中枢神经系统（CNS）的功能可通过血管生成和神经发生来修复。神经祖细胞（NPC）的增殖、分化和迁移受到神经干细胞龛内血管微环境的几个组成部分的调节。血管内皮细胞（VEC）构成血管，以及细胞外成分，通过与 NPC 直接接触来影响神经发生。此外，血管系统释放到 CNS 中的可溶性因子以旁分泌信号的形式增强神经发生。本篇综述的目的是强调血管微环境作为促进神经发生的介质的作用。
