奥他万星二磷酸盐与选定的伴随药物在模拟 Y 型部位给药时的可视相容性。

Visual compatibility of oritavancin diphosphate with selected coadministered drugs during simulated Y-site administration.

机构信息

College of Pharmacy, University of Minnesota, Minneapolis, MN 55455, USA.

出版信息

Am J Health Syst Pharm. 2010 Oct 1;67(19):1640-4. doi: 10.2146/ajhp100011.

DOI:10.2146/ajhp100011

PMID:20852166

Abstract

PURPOSE

The visual compatibility of the new intravenous antibiotic oritavancin diphosphate with various drugs commonly administered to patients in acute care settings was studied.

METHODS

Clinically used concentrations of 37 drugs, including antibiotics, sedatives, analgesics, and cardiovascular agents, were evaluated in 1:1 mixtures with oritavancin concentrations of 0.8, 1.2, and 2 mg/mL. Oritavancin solutions were prepared in 5% dextrose injection and mixed with each test drug solution. The mixtures were then visually observed over a period of four hours at room temperature. The pH of the mixtures was also determined immediately and four hours after mixing. Compatibility was defined as the absence of any color change, haze, fibers, particles, and precipitate.

RESULTS

Of the 37 tested drugs, 23 were visually compatible with all three concentrations of oritavancin over the four-hour study period. Drugs formulated at a basic or neutral pH were more likely to be incompatible with oritavancin.

CONCLUSION

Oritavancin diphosphate was visually incompatible with many intravenous drugs that are likely to be coadministered in acute care settings.

摘要

目的

研究新的静脉用抗生素奥他万星二磷酸盐与急性护理环境中常给患者使用的各种药物的视觉相容性。

方法

以临床使用浓度将 37 种药物（包括抗生素、镇静剂、镇痛药和心血管药物）与奥他万星浓度为 0.8、1.2 和 2mg/mL 的 1:1 混合物进行评估。奥他万星溶液在 5%葡萄糖注射液中配制，并与每种测试药物溶液混合。然后在室温下观察混合物在四个小时内的外观变化。混合物的 pH 值也在混合后立即和四小时后进行测定。相容性定义为无任何颜色变化、浑浊、纤维、颗粒和沉淀。