ClinVet International, Universitas, 9321 South Africa.
Vet Rec. 2010 Sep 18;167(12):442-5. doi: 10.1136/vr.c4456.
To determine the efficacy of a 12.5 per cent spot-on formulation of pyriprole (Prac-Tic; Novartis Animal Health) and that of a combination of 10 per cent imidacloprid and 2.5 per cent moxidectin (Advocate; Bayer Animal Health) against Sarcoptes scabiei on dogs, 20 naturally infested adult dogs were ranked according to their pretreatment mite counts, allocated to one of two groups and housed individually in pens. Two spot-on treatments with each product, 30 days apart, were administered. Mite counts and clinical assessments were performed on each dog two days before treatment, and 28, 60 and 90 days after treatment. Efficacy was measured on the basis of the presence or absence of live mites. Except for day 60 following treatment, on which a single dog in the group treated with pyriprole was positive, no live mites were found on the treated dogs during the assessments on days 28, 60 and 90. Thus, efficacy measured on the basis of this finding (day 90 assessment) was 100 per cent. On final assessment, all dogs treated with pyriprole had 100 per cent resolution of papules, but crusts resembling healing lesions were still present on two dogs. Those treated with imidacloprid and moxidectin had 100 per cent resolution of papules and crusts. Hair regrowth, to greater than 90 per cent of pretreatment hair cover, was observed on all 20 dogs.
为了确定 12.5%浓度的吡丙醚（Prac-Tic；诺华动物保健）滴剂和 10%吡虫啉与 2.5%莫昔克丁（Advocate；拜耳动物保健）合剂对犬疥螨的疗效，对 20 只自然感染的成年犬按其治疗前的螨计数进行分级，将其分配到两组中的一组，并单独饲养在围栏中。两种产品均进行两次滴剂处理，间隔 30 天。在治疗前两天、治疗后 28、60 和 90 天对每只狗进行螨计数和临床评估。疗效根据是否存在活螨来衡量。除了治疗后第 60 天，在接受吡丙醚治疗的组中，有一只狗呈阳性，在治疗后第 28、60 和 90 天的评估中，没有在治疗犬身上发现活螨。因此，根据这一发现（第 90 天评估），疗效为 100%。在最终评估时，所有接受吡丙醚治疗的狗的丘疹均 100%消退，但仍有两只狗存在类似于愈合病变的结痂。接受吡虫啉和莫昔克丁治疗的狗丘疹和结痂均 100%消退。所有 20 只狗的毛发再生率均大于治疗前毛发覆盖率的 90%。
