解脲支原体与非淋菌性尿道炎患者龟头-包皮炎的相关性。
Association of Mycoplasma genitalium with balanoposthitis in men with non-gonococcal urethritis.
机构信息
Department of Social Medicine, School of Social and Community Medicine, University of Bristol, 39 Whatley Road, Bristol BS8 2PS, UK.
出版信息
Sex Transm Infect. 2011 Feb;87(1):38-40. doi: 10.1136/sti.2010.044487. Epub 2010 Sep 18.
OBJECTIVE
To determine whether Mycoplasma genitalium is associated with balanitis and/or posthitis in a previous study of the role of M genitalium in men with acute non-gonococcal urethritis (NGU).
METHODS
In a previous study of men with acute NGU, the existence of balanitis and/or posthitis was recorded. Chlamydia trachomatis, M genitalium and ureaplasmas were sought in urethral swabs and urine using a direct fluorescent antibody test and in-house PCR, an in-house PCR and a culture method, respectively. Men were treated with doxycycline or erythromycin.
RESULTS
M genitalium was associated significantly (p = 0.01) with balanitis and/or posthitis in 114 men with acute NGU. This association persisted when there was control for C trachomatis and urethral discharge (p = 0.021, OR 4.1, 95% CI 1.2 to 13.5). C trachomatis and ureaplasmas were not associated with balanitis and/or posthitis.
CONCLUSION
Detection of M genitalium in men with acute NGU was associated significantly with balanitis and/or posthitis. The association is biologically plausible and may have a role in HIV-1 transmission and susceptibility.
目的
在先前研究解脲支原体（M 生殖器）在男性急性非淋球菌性尿道炎（NGU）中的作用时，确定 M 生殖器是否与阴茎头炎和/或包皮炎有关。
方法
在先前研究男性急性 NGU 时，记录了阴茎头炎和/或包皮炎的存在。使用直接荧光抗体试验和内部 PCR 分别在尿道拭子和尿液中寻找沙眼衣原体、M 生殖器和脲原体，使用内部 PCR 和培养方法。男性用多西环素或红霉素治疗。
结果
114 例急性 NGU 男性中，M 生殖器与阴茎头炎和/或包皮炎显著相关（p = 0.01）。当控制沙眼衣原体和尿道分泌物时，这种关联仍然存在（p = 0.021，OR 4.1，95%CI 1.2 至 13.5）。沙眼衣原体和脲原体与阴茎头炎和/或包皮炎无关。
结论
在急性 NGU 男性中检测到 M 生殖器与阴茎头炎和/或包皮炎显著相关。这种关联具有生物学意义，可能在 HIV-1 传播和易感性中起作用。
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