da Costa José António Tavares, Ribeiro A, Bogas M, Costa L, Varino C, Lucas R, Rodrigues A, Araújo D
Department of Rheumatology - ULSAM, EPE- Ponte de Lima, Largo Conde de Bertiandos, Ponte de Lima, Portugal.
Acta Reumatol Port. 2009 Oct-Dec;34(4):618-26.
Osteoporotic hip fractures (HF) are a major cause of morbidity and mortality with increasing familial, social and economic repercussions. The objectives of this paper were to evaluate the status vitae at 6 and 12 months of a cohort of patients with an osteoporotic HF and the risk factors for 12-month mortality as well as to evaluate the functional outcome and the overall health perception of these patients.
We conducted a 12-month follow-up evaluation of a cohort of 184 patients older than 65 years admitted to our centre with a non-pathological osteoporotic HF from January 1st to December 31st 2007. Baseline data collection was performed in the first 72 hours after admission and, 12 months later, a second evaluation was conducted, by telephone in order to ascertain their status vitae and functional status. The magnitude of sex--specific, age-adjusted associations between potential prognostic factors and mortality was estimated using hazard ratios (HR) and respective 95% confidence intervals (95%CI), calculated using Cox's proportional hazards model.
It was possible to ascertain the status vitae in 164 (89.1%) patients. Overall 12-months mortality was 26.8% (48.3% in males and 22.2% in females). Mortality was higher in patients that became bedridden, were unable to walk again, were admitted to a hospital during the follow-up for any cause and who became dependent in their daily living activities. After discharge, physical therapy and ability to walk again were associated with a lower risk of death. Most of the patients reported a decline of their overall health-related quality of life. More than 75% of patients became totally dependent after HF.
This study reinforces the HF poor outcome. Twelve-month mortality rates were similar to the estimates obtained in other studies, although the 6-month's mortality was higher. Physical deterioration and loss of independence in activities of daily living were evident in this study and constituted major factors for low self-esteem and deterioration of quality of life. Our findings may constitute an evidence for action in this particular population, with an active search for means to improve the outcome of HF in these patients.
骨质疏松性髋部骨折(HF)是发病和死亡的主要原因,对家庭、社会和经济的影响日益增大。本文的目的是评估一组骨质疏松性HF患者在6个月和12个月时的生命状态以及12个月死亡率的危险因素,并评估这些患者的功能结局和整体健康认知。
我们对2007年1月1日至12月31日入住我们中心的184例65岁以上非病理性骨质疏松性HF患者进行了为期12个月的随访评估。在入院后的前72小时进行基线数据收集,12个月后,通过电话进行第二次评估,以确定他们的生命状态和功能状态。使用风险比(HR)和各自的95%置信区间(95%CI)估计潜在预后因素与死亡率之间性别特异性、年龄调整后的关联强度,使用Cox比例风险模型计算。
可以确定164例(89.1%)患者的生命状态。总体12个月死亡率为26.8%(男性为48.3%,女性为22.2%)。卧床不起、无法再次行走、随访期间因任何原因入院以及日常生活活动变得依赖的患者死亡率较高。出院后,物理治疗和再次行走的能力与较低的死亡风险相关。大多数患者报告其整体健康相关生活质量下降。超过75%的患者在髋部骨折后完全依赖他人。
本研究强化了髋部骨折的不良结局。12个月死亡率与其他研究的估计相似,尽管6个月死亡率较高。本研究中身体功能恶化和日常生活活动独立性丧失明显,是导致自尊心低落和生活质量下降的主要因素。我们的研究结果可能为针对这一特定人群采取行动提供依据,积极寻找改善这些患者髋部骨折结局的方法。