Haentjens P, Autier P, Barette M, Venken K, Vanderschueren D, Boonen S
Department of Orthopaedics and Traumatology, Universitair Ziekenhuis Brussel, Vrije Universiteit Brussel, Laarbeeklaan 101, B-1090 Brussels, Belgium.
Bone. 2007 Dec;41(6):958-64. doi: 10.1016/j.bone.2007.08.026. Epub 2007 Aug 30.
We conducted a prospective study among elderly women with a first hip fracture to document survival and functional outcome and to determine whether outcomes differ by fracture type. The design was a one-year prospective cohort study in the context of standard day-to-day clinical practice. The main outcome measures were survival and functional outcome, both at hospital discharge and 1 year later. Functional outcome was assessed using the Rapid Disability Rating Scale version-2. Of the 170 women originally enrolled, 86 (51%) had an intertrochanteric and 84 (49%) a femoral neck fracture. There were no significant differences between the two groups with respect to median age (80 and 78 years, respectively), type and number of comorbidities and prefracture residence at the time of injury. At hospital discharge, intertrochanteric hip fracture patients had a higher mortality (p=0.006) and were functionally more impaired (p=0.005). One year later, mortality was still significantly higher after intertrochanteric fracture (relative risk 2.5; 95% confidence interval: 1.3 to 5.1; p=0.008), but functional outcome among surviving patients was similar in both groups. We conclude that intertrochanteric fractures are associated with increased mortality compared to femoral neck fractures. Functional outcome differs according to fracture type at hospital discharge, but these differences do not persist over time. These differences cannot be explained by differences in age or comorbidity. To address the mechanism(s) by which intertrochanteric fractures carry excess mortality compared to femoral neck fractures, future studies in hip fracture patients should include a comprehensive assessment of the degree of frailty, vitamin D status, and fall dynamics.
我们对首次发生髋部骨折的老年女性进行了一项前瞻性研究,以记录生存率和功能结局,并确定结局是否因骨折类型而异。该设计是在标准日常临床实践背景下进行的为期一年的前瞻性队列研究。主要结局指标是出院时和1年后的生存率和功能结局。使用快速残疾评定量表第2版评估功能结局。在最初纳入的170名女性中,86例(51%)为粗隆间骨折,84例(49%)为股骨颈骨折。两组在中位年龄(分别为80岁和78岁)、合并症类型和数量以及受伤时骨折前居住情况方面无显著差异。出院时,粗隆间髋部骨折患者的死亡率较高(p=0.006),功能受损更严重(p=0.005)。1年后,粗隆间骨折后的死亡率仍然显著较高(相对风险2.5;95%置信区间:1.3至5.1;p=0.008),但两组存活患者的功能结局相似。我们得出结论,与股骨颈骨折相比,粗隆间骨折与死亡率增加相关。出院时功能结局因骨折类型而异,但这些差异不会随时间持续存在。这些差异不能用年龄或合并症的差异来解释。为了探讨粗隆间骨折与股骨颈骨折相比导致额外死亡率的机制,未来对髋部骨折患者的研究应包括对衰弱程度、维生素D状态和跌倒动态的综合评估。