Key Laboratory for Advanced Materials and Institute of Fine Chemicals, East China University of Science and Technology, Shanghai 200237, China.
Chem Commun (Camb). 2010 Nov 7;46(41):7828-30. doi: 10.1039/c0cc01966f. Epub 2010 Sep 20.
A tertiary amine-catalyzed formal (3+n) annulation of 2-(acetoxymethyl)buta-2,3-dienoate with 1,n-binucleophiles has been developed, which provides a facile entry to heterocyclic compounds. The mechanism, involving tandem S(N)2'-S(N)2' substitution and Michael addition, has also been established.
一种三级胺催化的 2-(乙酰氧甲基)丁-2,3-二烯酸酯与 1,n-亲核试剂的形式（3+n）环化反应已被开发出来，为杂环化合物的合成提供了一种简便的方法。该反应涉及串联 S(N)2'-S(N)2'取代和迈克尔加成反应的机理也已建立。
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