三级胺引发的级联 S(N)2/环加成反应：在温和条件下高效构建复杂的氮杂杂环。
Tertiary amine-triggered cascade S(N)2/cycloaddition: an efficient construction of complex azaheterocycles under mild conditions.
机构信息
Key Laboratory for Advanced Materials and Institute of Fine Chemicals, East China University of Science and Technology, Meilong Road No. 130, Shanghai, 200237, P.R. China.
出版信息
Org Lett. 2012 Oct 5;14(19):5074-7. doi: 10.1021/ol302329b. Epub 2012 Sep 20.
PMID:22994290
Abstract
In this paper, an amine-triggered cascade S(N)2/cycloaddtion sequence between 2-(acetoxymethyl)buta-2,3-dienoate 1 and various π-system functionalized tosylamides 3 has been reported, which provides a facile method for stereoselective construction of structurally diverse azaheterocycles.
摘要
本文报道了一种在胺触发下，2-(乙酰氧基甲基)丁-2,3-二烯酸酯 1 和各种π-体系功能化对甲苯磺酰胺 3 之间发生的级联 S(N)2/环加成序列，该序列为立体选择性构建结构多样的氮杂环提供了一种简便的方法。
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