Department of Microbiology, Institute for Genomic Biology, University of Illinois at Urbana-Champaign, 601 S. Goodwin Avenue, Urbana, IL 61801, USA.
Am J Primatol. 2011 Feb;73(2):119-26. doi: 10.1002/ajp.20851. Epub 2010 Sep 17.
Humans and baboons (Papio spp.) share considerable anatomical and physiological similarities in their reproductive tracts. Given the similarities, it is reasonable to expect that the normal vaginal microbial composition (microbiota) of baboons would be similar to that of humans. We have used a 16S rRNA phylogenetic approach to assess the composition of the baboon vaginal microbiota in a set of nine animals from a captive facility and six from the wild. Results show that although Gram-positive bacteria dominate in baboons as they do in humans, there are major differences between the vaginal microbiota of baboons and that of humans. In contrast to humans, the species of Gram-positive bacteria (Firmicutes) were taxa other than Lactobacillus species. In addition, some groups of Gram-negative bacteria that are not normally abundant in humans were found in the baboon samples. A further level of difference was also seen even within the same bacterial phylogenetic group, as baboon strains tended to be more phylogenetically distinct from human strains than human strains were with each other. Finally, results of our analysis suggests that co-evolution of microbes and their hosts cannot account for the major differences between the microbiota of baboons and that of humans because divergences between the major bacterial genera were too ancient to have occurred since primates evolved. Instead, the primate vaginal tracts appear to have acquired discrete subsets of bacteria from the vast diversity of bacteria available in the environment and established a community responsive to and compatible with host species physiology.
人类和狒狒（Papio spp.）在生殖道方面具有相当程度的解剖学和生理学相似性。鉴于这种相似性，有理由期望狒狒的正常阴道微生物组成（微生物群）与人类相似。我们使用 16S rRNA 系统发育方法评估了一组来自圈养设施的 9 只动物和来自野外的 6 只狒狒的阴道微生物群组成。结果表明，尽管革兰氏阳性菌在狒狒中像在人类中一样占主导地位，但狒狒阴道微生物群与人类阴道微生物群之间存在重大差异。与人类不同的是，革兰氏阳性菌（Firmicutes）的物种是除乳杆菌属以外的其他物种。此外，在狒狒样本中还发现了一些在人类中通常不丰富的革兰氏阴性菌群体。即使在同一细菌系统发育群内，也存在进一步的差异，因为狒狒菌株比人类菌株彼此之间更倾向于与人类菌株在系统发育上有更大的区别。最后，我们的分析结果表明，微生物与其宿主的共同进化并不能解释狒狒和人类微生物群之间的主要差异，因为主要细菌属之间的分歧太古老了，不可能自灵长类动物进化以来就已经发生了。相反，灵长类动物的阴道似乎从环境中大量存在的细菌中获得了离散的细菌子集，并建立了一个对宿主物种生理学有反应且与之兼容的群落。
