Laboratory of Immunoregulation and Mucosal Immunology, Department of Respiratory Diseases, Ghent University, Belgium.
Eur J Immunol. 2010 Aug;40(8):2112-8. doi: 10.1002/eji.201040562.
Lung DC bridge innate and adaptive immunity, and depending on the context, induce Th1, Th2 or Th17 response, to optimally clear infections. Conversely, lung DC can also prevent overt and harmful immune responses to harmless inhaled antigens via induction of Treg cells or via induction of neutralizing mucosal IgA antibodies. Here, we propose that these functions are not the result of a single population of DC, and instead, subsets of DC perform specialized functions.
肺脏 DC 桥接先天和适应性免疫，并根据具体情况诱导 Th1、Th2 或 Th17 反应，以最佳清除感染。相反，肺脏 DC 也可以通过诱导 Treg 细胞或通过诱导中和黏膜 IgA 抗体来防止对无害吸入抗原的过度和有害免疫反应。在这里，我们提出这些功能不是单个 DC 群体的结果，而是 DC 的亚群执行专门的功能。
